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DC Field | Value | Language |
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dc.contributor.author | Singh, R | - |
dc.contributor.author | Miao, T | - |
dc.contributor.author | Symonds, AL | - |
dc.contributor.author | Omodho, B | - |
dc.contributor.author | Li, S | - |
dc.contributor.author | Wang, P | - |
dc.date.accessioned | 2017-06-07T12:11:29Z | - |
dc.date.available | 2017-04-28 | - |
dc.date.available | 2017-06-07T12:11:29Z | - |
dc.date.issued | 2017-05-22 | - |
dc.identifier.citation | Singh R, Miao T, Symonds AL, Omodho B, Li S, Wang P. Egr2 and 3 Inhibit T-bet–Mediated IFN-γ Production in T Cells. The Journal of Immunology. 2017 Jun 1;198(11):4394-402. | en_US |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/14683 | - |
dc.description.abstract | T-bet is important for differentiation of cytotoxic CD8 and Th1 CD4 T cells. We have discovered that Egr2 and 3 are potent inhibitors of T-bet function in CD4 and CD8 effector T cells. Egr2 and 3 were essential to suppress Th1 differentiation in Th2 and Th17 conditions in vitro and also to control IFN-g–producing CD4 and CD8 T cells in response to virus infection. Together with Egr2 and 3, T-bet is induced in naive T cells by Ag stimulation, but Egr2 and 3 expression was inhibited by Th1–inducing cytokines. We found that Egr2 and 3 physically interact with the T-box domain of T-bet, blocking T-bet DNA binding and inhibiting T-bet–mediated production of IFN-g. Thus, Egr2 and 3 are antagonists of T-bet function in effector T cells and are important for the control of inflammatory responses of T cells. The Journal of Immunology, 2017, 198: 000–000. | en_US |
dc.language.iso | en | en_US |
dc.publisher | American Association of Immunologists | en_US |
dc.title | Egr2 and 3 Inhibit T-bet-Mediated IFN-γ Production in T Cells. | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.4049/jimmunol.1602010. | - |
dc.relation.isPartOf | Journal of Immunology | - |
pubs.publication-status | Published | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
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Fulltext.pdf | 2.22 MB | Adobe PDF | View/Open |
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