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DC Field | Value | Language |
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dc.contributor.author | Paternoster, L | - |
dc.contributor.author | Standl, M | - |
dc.contributor.author | Chen, C-M | - |
dc.contributor.author | Ramasamy, A | - |
dc.contributor.author | Bonnelykke, K | - |
dc.contributor.author | Duijts, L | - |
dc.contributor.author | Ferreira, MA | - |
dc.contributor.author | Alves, AC | - |
dc.contributor.author | Thyssen, JP | - |
dc.contributor.author | Albrecht, E | - |
dc.contributor.author | Baurecht, H | - |
dc.contributor.author | Melen, E | - |
dc.contributor.author | Boomsma, DI | - |
dc.contributor.author | Custovic, A | - |
dc.contributor.author | Jacobsson, B | - |
dc.contributor.author | Probst-Hensch, NM | - |
dc.contributor.author | Palmer, LJ | - |
dc.contributor.author | Glass, D | - |
dc.contributor.author | Hakonarson, H | - |
dc.contributor.author | Melbye, M | - |
dc.contributor.author | Jarvis, DL | - |
dc.contributor.author | Jaddoe, VWV | - |
dc.contributor.author | Gieger, C | - |
dc.contributor.author | Strachan, DP | - |
dc.contributor.author | Martin, NG | - |
dc.contributor.author | Jarvelin, M-R | - |
dc.contributor.author | Heinrich, J | - |
dc.contributor.author | Evans, DM | - |
dc.contributor.author | Weidinger, S | - |
dc.contributor.author | Feenstra, B | - |
dc.contributor.author | Sleiman, PMA | - |
dc.contributor.author | Hysi, P | - |
dc.contributor.author | Warrington, NM | - |
dc.contributor.author | Curjuric, I | - |
dc.contributor.author | Myhre, R | - |
dc.contributor.author | Curtin, JA | - |
dc.contributor.author | Groen-Blokhuis, MM | - |
dc.contributor.author | Kerkhof, M | - |
dc.contributor.author | Saaf, A | - |
dc.contributor.author | Franke, A | - |
dc.contributor.author | Ellinghaus, D | - |
dc.contributor.author | Foelster-Holst, R | - |
dc.contributor.author | Dermitzakis, E | - |
dc.contributor.author | Montgomery, SB | - |
dc.contributor.author | Prokisch, H | - |
dc.contributor.author | Heim, K | - |
dc.contributor.author | Hartikainen, A-L | - |
dc.contributor.author | Pouta, A | - |
dc.contributor.author | Pekkanen, J | - |
dc.contributor.author | Blakemore, AIF | - |
dc.contributor.author | Buxton, JL | - |
dc.contributor.author | Kaakinen, M | - |
dc.contributor.author | Duffy, DL | - |
dc.contributor.author | Madden, PA | - |
dc.contributor.author | Heath, AC | - |
dc.contributor.author | Montgomery, GW | - |
dc.contributor.author | Thompson, PJ | - |
dc.contributor.author | Matheson, MC | - |
dc.contributor.author | Le Souef, P | - |
dc.contributor.author | St Pourcain, B | - |
dc.contributor.author | Smith, GD | - |
dc.contributor.author | Henderson, J | - |
dc.contributor.author | Kemp, JP | - |
dc.contributor.author | Timpson, NJ | - |
dc.contributor.author | Deloukas, P | - |
dc.contributor.author | Ring, SM | - |
dc.contributor.author | Wichmann, H-E | - |
dc.contributor.author | Mueller-Nurasyid, M | - |
dc.contributor.author | Novak, N | - |
dc.contributor.author | Klopp, N | - |
dc.contributor.author | Rodriguez, E | - |
dc.contributor.author | McArdle, W | - |
dc.contributor.author | Linneberg, A | - |
dc.contributor.author | Menne, T | - |
dc.contributor.author | Nohr, EA | - |
dc.contributor.author | Hofman, A | - |
dc.contributor.author | Uitterlinden, AG | - |
dc.contributor.author | van Duijin, CM | - |
dc.contributor.author | Rivadeneira, F | - |
dc.contributor.author | de Jongste, JC | - |
dc.contributor.author | van der Valk, RJP | - |
dc.contributor.author | Wjst, M | - |
dc.contributor.author | Jogi, R | - |
dc.contributor.author | Geller, F | - |
dc.contributor.author | Boyd, HA | - |
dc.contributor.author | Murray, JC | - |
dc.contributor.author | Kim, C | - |
dc.contributor.author | Mentch, F | - |
dc.contributor.author | March, M | - |
dc.contributor.author | Mangino, M | - |
dc.contributor.author | Spector, TD | - |
dc.contributor.author | Bataille, V | - |
dc.contributor.author | Pennell, CE | - |
dc.contributor.author | Holt, PG | - |
dc.contributor.author | Sly, P | - |
dc.contributor.author | Tiesler, CMT | - |
dc.contributor.author | Thiering, E | - |
dc.contributor.author | Illig, T | - |
dc.contributor.author | Imboden, M | - |
dc.contributor.author | Nystad, W | - |
dc.contributor.author | Simpson, A | - |
dc.contributor.author | Hottenga, J-J | - |
dc.contributor.author | Postma, D | - |
dc.contributor.author | Koppelman, GH | - |
dc.contributor.author | Smit, HA | - |
dc.contributor.author | Soderhall, C | - |
dc.contributor.author | Chawes, B | - |
dc.contributor.author | Kreiner-Moller, E | - |
dc.contributor.author | Bisgaard, H | - |
dc.date.accessioned | 2017-06-07T15:52:54Z | - |
dc.date.available | 2012-02-01 | - |
dc.date.available | 2017-06-07T15:52:54Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Nature Genetics, 44(2): pp. 187 - 192, (2012) | en_US |
dc.identifier.issn | 1061-4036 | - |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/14699 | - |
dc.description.abstract | Atopic dermatitis (AD) is a commonly occurring chronic skin disease with high heritability. Apart from filaggrin (FLG), the genes influencing atopic dermatitis are largely unknown. We conducted a genome-wide association meta-analysis of 5,606 affected individuals and 20,565 controls from 16 population-based cohorts and then examined the ten most strongly associated new susceptibility loci in an additional 5,419 affected individuals and 19,833 controls from 14 studies. Three SNPs reached genome-wide significance in the discovery and replication cohorts combined, including rs479844 upstream of OVOL1 (odds ratio (OR) = 0.88, P = 1.1 × 10−13) and rs2164983 near ACTL9 (OR = 1.16, P = 7.1 × 10−9), both of which are near genes that have been implicated in epidermal proliferation and differentiation, as well as rs2897442 in KIF3A within the cytokine cluster at 5q31.1 (OR = 1.11, P = 3.8 × 10−8). We also replicated association with the FLG locus and with two recently identified association signals at 11q13.5 (rs7927894; P = 0.008) and 20q13.33 (rs6010620; P = 0.002). Our results underline the importance of both epidermal barrier function and immune dysregulation in atopic dermatitis pathogenesis. | en_US |
dc.format.extent | 187 - 192 (6) | - |
dc.language | English | - |
dc.language.iso | en | en_US |
dc.publisher | Nature Publishing Group | en_US |
dc.subject | Atopic dermatitis | en_US |
dc.subject | Epidemiology | en_US |
dc.subject | Genetic predisposition to disease | en_US |
dc.subject | Genome-wide association studies | en_US |
dc.title | Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.1038/ng.1017 | - |
dc.relation.isPartOf | NATURE GENETICS | - |
pubs.issue | 2 | - |
pubs.publication-status | Published | - |
pubs.volume | 44 | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
Files in This Item:
File | Description | Size | Format | |
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FullText.pdf | 1.28 MB | Adobe PDF | View/Open |
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