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http://bura.brunel.ac.uk/handle/2438/15103
Title: | Errors on the Trail Making Test Are Associated with Right Hemispheric Frontal Lobe Damage in Stroke Patients |
Authors: | Kopp, B Roesser, N Tabeling, S Stuerenburg, HJ de Haan, B Karnath, H-O Wessel, K |
Keywords: | Science & Technology;Life Sciences & Biomedicine;Clinical Neurology;Neurosciences & Neurology;CARD SORTING TEST;VERBAL FLUENCY;CATEGORY TEST;BRAIN-DAMAGE;LESIONS;DEFICITS;ABILITIES;CORTEX |
Issue Date: | 2015 |
Publisher: | HINDAWI PUBLISHING CORPORATION |
Citation: | BEHAVIOURAL NEUROLOGY, (2015) |
Abstract: | Measures of performance on the Trail Making Test (TMT) are among the most popular neuropsychological assessment techniques. Completion time on TMT-A is considered to provide a measure of processing speed, whereas completion time on TMT-B is considered to constitute a behavioral measure of the ability to shift between cognitive sets (cognitive flexibility), commonly attributed to the frontal lobes. However, empirical evidence linking performance on the TMT-B to localized frontal lesions is mostly lacking. Here, we examined the association of frontal lesions following stroke with TMT-B performance measures (i.e., completion time and completion accuracy measures) using voxel-based lesion-behavior mapping, with a focus on right hemispheric frontal lobe lesions. Our results suggest that the number of errors, but not completion time on the TMT-B, is associated with right hemispheric frontal lesions. This finding contradicts common clinical practice—the use of completion time on the TMT-B to measure cognitive flexibility, and it underscores the need for additional research on the association between cognitive flexibility and the frontal lobes. Further work in a larger sample, including left frontal lobe damage and with more power to detect effects of right posterior brain injury, is necessary to determine whether our observation is specific for right frontal lesions. |
URI: | http://bura.brunel.ac.uk/handle/2438/15103 |
DOI: | http://dx.doi.org/10.1155/2015/309235 |
ISSN: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000355135200001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=f12c8c83318cf2733e615e54d9ed7ad5 ARTN 309235 http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000355135200001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=f12c8c83318cf2733e615e54d9ed7ad5 ARTN 309235 0953-4180 1875-8584 |
Appears in Collections: | Dept of Life Sciences Research Papers |
Files in This Item:
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Fulltext.pdf | 2.06 MB | Adobe PDF | View/Open |
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