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DC Field | Value | Language |
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dc.contributor.author | Lidzba, K | - |
dc.contributor.author | de Haan, B | - |
dc.contributor.author | Wilke, M | - |
dc.contributor.author | Krägeloh-Mann, I | - |
dc.contributor.author | Staudt, M | - |
dc.date.accessioned | 2017-09-18T13:29:17Z | - |
dc.date.available | 2017-10 | - |
dc.date.available | 2017-09-18T13:29:17Z | - |
dc.date.issued | 2017-05-23 | - |
dc.identifier.citation | Lidzba K, de Haan B, Wilke M, Krägeloh-Mann I, Staudt M. Lesion characteristics driving right-hemispheric language reorganization in congenital left-hemispheric brain damage. Brain and language. 2017 Oct 1;173:1-9. | en_US |
dc.identifier.issn | 0093-934X | - |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/15160 | - |
dc.description.abstract | Pre- or perinatally acquired (“congenital”) left-hemispheric brain lesions can be compensated for by reorganizing language into homotopic brain regions in the right hemisphere. Language comprehension may be hemispherically dissociated from language production. We investigated the lesion characteristics driving inter-hemispheric reorganization of language comprehension and language production in 19 patients (7 - 32 years; eight females) with congenital left-hemispheric brain lesions (periventricular lesions [n=11] and middle cerebral artery infarctions [n=8]) by fMRI. 16 / 17 patients demonstrated reorganized language production, while 7 / 19 patients had reorganized language comprehension. Lesions to the insular cortex and the temporo-parietal junction (predominantly supramarginal gyrus) were significantly more common in patients in whom both, language production and comprehension were reorganized. These areas belong to the dorsal stream of the language network, participating in the auditory-motor integration of language. Our data suggest that the integrity of this stream might be crucial for a normal left-lateralized language development. | en_US |
dc.description.sponsorship | This work was supported by the German research council [collaborative research centre 550, to KL, and grant number WI3630, to MW], as well as by the intramural funding programme fortüne [University Tübingen; grant number F1274155] and the Ministry of Science and the 27 Arts, Baden-Württemberg & European Social Fund [“Margarete-von-Wrangell Habilitationsprogramm” to KL]. | en_US |
dc.format.extent | 1 - 9 | - |
dc.language.iso | en | en_US |
dc.subject | Congenital brain lesion | en_US |
dc.subject | Language reorganisation | en_US |
dc.subject | Language comprehension | en_US |
dc.subject | Lesion-symptom mapping | en_US |
dc.title | Lesion characteristics driving right-hemispheric language reorganization in congenital left-hemispheric brain damage | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/j.bandl.2017.04.006 | - |
dc.relation.isPartOf | Brain and Language | - |
pubs.notes | publisher: Elsevier articletitle: Lesion characteristics driving right-hemispheric language reorganization in congenital left-hemispheric brain damage journaltitle: Brain and Language articlelink: http://dx.doi.org/10.1016/j.bandl.2017.04.006 content_type: article copyright: © 2017 Published by Elsevier Inc. | - |
pubs.publication-status | Published | - |
pubs.volume | 173 | - |
Appears in Collections: | Dept of Health Sciences Research Papers |
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Fulltext.pdf | 457.11 kB | Adobe PDF | View/Open |
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