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http://bura.brunel.ac.uk/handle/2438/16148
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DC Field | Value | Language |
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dc.contributor.author | Kippelen, P | - |
dc.contributor.author | Anderson, SD | - |
dc.contributor.author | Hallstrand, TS | - |
dc.coverage.spatial | United States | - |
dc.date.accessioned | 2018-04-27T09:53:09Z | - |
dc.date.available | 2018-05 | - |
dc.date.available | 2018-04-27T09:53:09Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Immunol Allergy Clin North Am, 2018, 38 (2), pp. 165 - 182 | en_US |
dc.identifier.issn | https://www.ncbi.nlm.nih.gov/pubmed/29631728 | - |
dc.identifier.issn | S0889-8561(18)30008-0 | - |
dc.identifier.issn | https://www.ncbi.nlm.nih.gov/pubmed/29631728 | - |
dc.identifier.issn | S0889-8561(18)30008-0 | - |
dc.identifier.issn | 1557-8607 | - |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/16148 | - |
dc.description.abstract | Exercise is a common trigger of bronchoconstriction. In recent years, there has been increased understanding of the pathophysiology of exercise-induced bronchoconstriction. Although evaporative water loss and thermal changes have been recognized stimuli for exercise-induced bronchoconstriction, accumulating evidence points toward a pivotal role for the airway epithelium in orchestrating the inflammatory response linked to exercise-induced bronchoconstriction. Overproduction of inflammatory mediators, underproduction of protective lipid mediators, and infiltration of the airways with eosinophils and mast cells are all established contributors to exercise-induced bronchoconstriction. Sensory nerve activation and release of neuropeptides maybe important in exercise-induced bronchoconstriction, but further research is warranted. | en_US |
dc.format.extent | 165 - 182 | - |
dc.language | eng | - |
dc.language.iso | en | en_US |
dc.subject | Eicosanoids | en_US |
dc.subject | Eosinophils | en_US |
dc.subject | Epithelium | en_US |
dc.subject | Hyperpnea | en_US |
dc.subject | Mast cells | en_US |
dc.subject | Osmolarity | en_US |
dc.subject | Sensory nerves | en_US |
dc.subject | Water loss | en_US |
dc.title | Mechanisms and Biomarkers of Exercise-Induced Bronchoconstriction. | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/j.iac.2018.01.008 | - |
dc.relation.isPartOf | Immunol Allergy Clin North Am | - |
pubs.issue | 2 | - |
pubs.publication-status | Published | - |
pubs.volume | 38 | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
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Fulltext.pdf | 475.88 kB | Adobe PDF | View/Open |
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