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DC Field | Value | Language |
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dc.contributor.author | Mangogna, A | - |
dc.contributor.author | Belmonte, B | - |
dc.contributor.author | Agostinis, C | - |
dc.contributor.author | Giuseppe, R | - |
dc.contributor.author | Gulino, A | - |
dc.contributor.author | Ferrara, I | - |
dc.contributor.author | Zanconati, F | - |
dc.contributor.author | Tripodo, C | - |
dc.contributor.author | Romano, F | - |
dc.contributor.author | Kishore, U | - |
dc.contributor.author | Bulla, R | - |
dc.date.accessioned | 2018-07-19T13:16:39Z | - |
dc.date.available | 2018-07-16 | - |
dc.date.available | 2018-07-19T13:16:39Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Frontiers in Immunology, 2018 | en_US |
dc.identifier.issn | 1664-3224 | - |
dc.identifier.issn | http://dx.doi.org/10.3389/fimmu.2018.01748 | - |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/16591 | - |
dc.description.abstract | Surfactant protein D (SP-D) is a pattern recognition molecule belonging to the Collectin (collagen-containing C-type lectin) family that has pulmonary as well as extra-pulmonary existence. In the lungs, it is a well-established opsonin that can agglutinate a range of microbes, and enhance their clearance via phagocytosis and super-oxidative burst. It can interfere with allergen-IgE interaction and suppress basophil and mast cell activation. However, it is now becoming evident that SP-D is likely to be an innate immune surveillance molecule against tumor development. SP-D has been shown to induce apoptosis in sensitized eosinophils derived from allergic patients and a leukemic cell line via p53 pathway. Recently, SP-D has been shown to suppress lung cancer progression via interference with the epidermal growth factor signaling. In addition, a truncated form of recombinant human SP-D has been reported to induce apoptosis in pancreatic adenocarcinoma via Fas-mediated pathway in a p53-independent manner. To further establish a correlation between SP-D presence/levels and normal and cancer tissues, we performed a bioinformatics analysis, using Oncomine dataset and the survival analysis platforms Kaplan-Meier plotter, to assess if SP-D can serve as a potential prognostic marker for human lung cancer, in addition to human gastric, breast and ovarian cancers. We also analyzed immunohistochemically the presence of SP-D in normal and tumor human tissues. We conclude that (1) in the lung, gastric and breast cancers, there is a lower expression of SP-D than normal tissues; (2) in ovarian cancer, there is a higher expression of SP-D than normal tissue; and (3) in lung cancer, the presence of SP-D could be associated with a favorable prognosis. On the contrary, at non-pulmonary sites such as gastric, breast and ovarian cancers, the presence of SP-D could be associated with unfavorable prognosis. Correlation between the levels of SP-D and overall survival requires further investigation. Our analysis involves a large number of dataset; therefore, any trend observed is reliable. Despite apparent complexity within the results, it is evident that cancer tissues that produce less levels of SP-D compared to their normal tissue counterparts, are probably less susceptible to SP-D-mediated immune surveillance mechanisms via infiltrating immune cells. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Frontiers Media | en_US |
dc.title | Pathological significance and prognostic value of Surfactant Protein D in cancer | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.3389/fimmu.2018.01748 | - |
dc.relation.isPartOf | Frontiers in Immunology | - |
pubs.publication-status | Accepted | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
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File | Description | Size | Format | |
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Fulltext.pdf | 4.01 MB | Adobe PDF | View/Open |
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