Please use this identifier to cite or link to this item:
http://bura.brunel.ac.uk/handle/2438/16638
Title: | Transcription factors early growth response gene (Egr) 2 and 3 control inflammatory responses of tolerant T cells |
Authors: | Omodho, B Miao, T Symonds, AL Singh, R Li, S Wang, P |
Keywords: | Egr2;T cells;Tolerance |
Issue Date: | 3-Jan-2018 |
Publisher: | Wiley |
Citation: | Omodho B, Miao T, Symonds AL, Singh R, Li S, Wang P. Transcription factors early growth response gene (Egr) 2 and 3 control inflammatory responses of tolerant T cells. Immunity, inflammation and disease. 2018 Jun;6(2):221-33. |
Abstract: | Introduction: Impaired proliferation and production of IL2 are the hallmarks of experimental T cell tolerance. However, in most autoimmune diseases, autoreactive T cells do not display hyper proliferation, but inflammatory phenotypes. Methods: We have now demonstrated that the transcription factors Egr2 and 3 are important for the control of inflammatory cytokine production by tolerant T cells, but not for tolerance induction. Results: In the absence of Egr2 and 3, T cell tolerance, as measured by impaired proliferation and production of IL2, can still be induced, but tolerant T cells produced high levels of inflammatory cytokines. Egr2 and 3 regulate expression of differentiation repressors and directly inhibit T-bet function in T cells. Indeed, decreased expression of differentiation repressors, such as Id3 and Tcf1, and increased expression of inflammatory transcription factors, such as RORgt and Bhlhe40 were found in Egr2/3 deficient T cells under tolerogenic conditions. In addition, T-bet was co-expressed with Egr2 in tolerant T cells and Egr2/3 defects leads to production of high levels of IFNg in tolerant T cells. Conclusions: Our findings demonstrated that despite impaired proliferation and IL2 production, tolerant T cells can display inflammatory responses in response to antigen stimulation and this is controlled at least partly by Egr2 and 3. |
URI: | http://bura.brunel.ac.uk/handle/2438/16638 |
DOI: | http://dx.doi.org/10.1002/iid3.210 |
ISSN: | 2050-4527 |
Appears in Collections: | Dept of Life Sciences Research Papers |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
FullText.pdf | 2.97 MB | Adobe PDF | View/Open |
Items in BURA are protected by copyright, with all rights reserved, unless otherwise indicated.