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DC Field | Value | Language |
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dc.contributor.author | McCarthy, RR | - |
dc.contributor.author | Mazon-Moya, MJ | - |
dc.contributor.author | Moscoso, JA | - |
dc.contributor.author | Hao, Y | - |
dc.contributor.author | Lam, JS | - |
dc.contributor.author | Bordi, C | - |
dc.contributor.author | Mostowy, S | - |
dc.contributor.author | Filloux, A | - |
dc.date.accessioned | 2018-10-12T10:20:46Z | - |
dc.date.available | 2017-03-06 | - |
dc.date.available | 2018-10-12T10:20:46Z | - |
dc.date.issued | 2017-03-06 | - |
dc.identifier.citation | McCarthy, R., Mazon-Moya, M., Moscoso, J. et al. Cyclic-di-GMP regulates lipopolysaccharide modification and contributes to Pseudomonas aeruginosa immune evasion. Nat Microbiol 2, 17027 | en_US |
dc.identifier.issn | 2058-5276 | - |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/16968 | - |
dc.description.abstract | Pseudomonas aeruginosa is a Gram-negative bacterial pathogen associated with acute and chronic infections. The universal c-di-GMP second messenger is instrumental in the switch from a motile lifestyle to resilient biofilm as in the cystic fibrosis lung. The SadC diguanylate cyclase is associated with this patho-adaptive transition. Here we identified an unrecognized SadC partner, WarA, which we show is a methyltransferase in complex with a putative kinase WarB. We established that WarA binds to c-di-GMP, which potentiates its methyltransferase activity. Together, WarA and WarB have structural similarities with the bi-functional Escherichia coli LPS O antigen regulator WbdD. Strikingly, WarA influences P. aeruginosa O antigen modal distribution and interacts with the LPS biogenesis machinery. LPS is known to modulate the immune response in the host, and by using a zebrafish infection model, we implicate WarA in the ability of P. aeruginosa to evade detection by the host. | en_US |
dc.description.sponsorship | BBSRC & Wellcome Trust | en_US |
dc.format.extent | 17027 - 17027 | - |
dc.language.iso | en | en_US |
dc.publisher | Nature Research | en_US |
dc.rights | The final authenticated version is available online at https://doi.org/10.1038/nmicrobiol.2017.27 | en_US |
dc.title | Cyclic-di-GMP regulates lipopolysaccharide modification and contributes to Pseudomonas aeruginosa immune evasion | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.1038/nmicrobiol.2017.27 | - |
dc.relation.isPartOf | Nature Microbiology | - |
pubs.publication-status | Published | - |
pubs.volume | 2 | - |
dc.identifier.eissn | 2058-5276 | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
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FullText.pdf | 1.79 MB | Adobe PDF | View/Open |
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