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http://bura.brunel.ac.uk/handle/2438/16995
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DC Field | Value | Language |
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dc.contributor.author | Beaney, KE | - |
dc.contributor.author | Cooper, JA | - |
dc.contributor.author | McLachlan, S | - |
dc.contributor.author | Wannamethee, SG | - |
dc.contributor.author | Jefferis, BJ | - |
dc.contributor.author | Whincup, P | - |
dc.contributor.author | Ben-Shlomo, Y | - |
dc.contributor.author | Price, JF | - |
dc.contributor.author | Kumari, M | - |
dc.contributor.author | Wong, A | - |
dc.contributor.author | Ong, K | - |
dc.contributor.author | Hardy, R | - |
dc.contributor.author | Kuh, D | - |
dc.contributor.author | Kivimaki, M | - |
dc.contributor.author | Kangas, AJ | - |
dc.contributor.author | Soininen, P | - |
dc.contributor.author | Ala-Korpela, M | - |
dc.contributor.author | Drenos, F | - |
dc.contributor.author | Humphries, SE | - |
dc.date.accessioned | 2018-10-15T15:51:25Z | - |
dc.date.available | 2016-08-22 | - |
dc.date.available | 2018-10-15T15:51:25Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Cardiovascular diabetology, 2016, 15 (1), pp. 115 - 115 | en_US |
dc.identifier.issn | 1475-2840 | - |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/16995 | - |
dc.description.abstract | Aims An intergenic locus on chromosome 1 (lead SNP rs10911021) was previously associated with coronary heart disease (CHD) in type 2 diabetes (T2D). Using data from the UCLEB consortium we investigated the relationship between rs10911021 and CHD in T2D, whether rs10911021 was associated with levels of amino acids involved in the γ-glutamyl cycle or any conventional risk factors (CRFs) for CHD in the T2D participants. Methods Four UCLEB studies (n = 6531) had rs10911021 imputation, CHD in T2D, CRF and metabolomics data determined using a nuclear magnetic resonance based platform. Results The expected direction of effect between rs10911021 and CHD in T2D was observed (1377 no CHD/160 CHD; minor allele OR 0.80, 95 % CI 0.60–1.06) although this was not statistically significant (p = 0.13). No association between rs10911021 and CHD was seen in non-T2D participants (11218 no CHD/1274 CHD; minor allele OR 1.00 95 % CIs 0.92–1.10). In T2D participants, while no associations were observed between rs10911021 and the nine amino acids measured, rs10911021 was associated with HDL-cholesterol (p = 0.0005) but the minor “protective” allele was associated with lower levels (−0.034 mmol/l per allele). Focusing more closely on the HDL-cholesterol subclasses measured, we observed that rs10911021 was associated with six large HDL particle measures in T2D (all p < 0.001). No significant associations were seen in non-T2D subjects. Conclusions Our findings are consistent with a true association between rs10911021 and CHD in T2D. The protective minor allele was associated with lower HDL-cholesterol and reductions in HDL particle traits. Our results indicate a complex relationship between rs10911021 and CHD in T2D. | en_US |
dc.description.sponsorship | British Heart Foundation Programme Grant | en_US |
dc.format.extent | 115 - 115 | - |
dc.language.iso | en | en_US |
dc.publisher | Springer Verlag | en_US |
dc.subject | Coronary heart disease | en_US |
dc.subject | Metabolomics | en_US |
dc.subject | HDL-cholesterol | en_US |
dc.subject | Genetic risk | en_US |
dc.title | Variant rs10911021 that associates with coronary heart disease in type 2 diabetes, is associated with lower concentrations of circulating HDL cholesterol and large HDL particles but not with amino acids | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.1186/s12933-016-0435-0 | - |
dc.relation.isPartOf | Cardiovascular diabetology | - |
pubs.issue | 1 | - |
pubs.publication-status | Published | - |
pubs.volume | 15 | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
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FullText.pdf | 1.44 MB | Adobe PDF | View/Open |
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