Please use this identifier to cite or link to this item: http://bura.brunel.ac.uk/handle/2438/17052
Title: A Method for Determining Local Pulse Wave Velocity in Human Ascending Aorta from Sequential Ultrasound Measurements of Diameter and Velocity
Authors: Khir, AW
Negoita, M
Issue Date: 2018
Publisher: IOP Publishing
Citation: Physiological Measurement
Abstract: Background: Pulse wave velocity (PWV) is an indicator of arterial stiffness, and predicts 2 cardiovascular events independently of blood pressure. Currently, PWV is commonly measured by the foot-to-foot technique thus giving a global estimate of large arterial stiffness. However, and despite its importance, methods to measure the stiffness of the ascending aorta are limited. Aim: To introduce a method for calculating local PWV in the human ascending aorta using noninvasive ultrasound measurements of its diameter (D) and flow velocity (U). Methods: 10 participants (4 females) were recruited from Brunel University students. Ascending aortic diameter and velocity were recorded with a GE Vivid E95 equipped with a 1.5-4.5MHz phased array transducer using M-mode in the parasternal long axis view and pulse wave Doppler in the apical 5 chamber view respectively. Groups of 6 consecutive heartbeats were selected from each 20s run based on the most similar cycle length resulting 3 groups for D and 3 for U each with 6 waveforms. Each D waveform was paired with each U waveform to calculate PWV using ln(D)U-loop method. Results: The diastolic portions of the diameters or velocities waveforms were truncated to allow the pairs to have equal length and were used to construct ln(D)U-loops. The trimmed average, excluding 10% of extreme values, resulting from the 324 loops was considered representative for each participant. Overall mean local PWV for all participants was 4.1(SD = 0.9)m/s. Conclusions: Local PWV can be measured non-invasively in the ascending aorta using ultrasound measurements of diameter and flow velocity This should facilitate more widespread assessment of ascending aortic stiffness in larger studies.
URI: http://bura.brunel.ac.uk/handle/2438/17052
DOI: http://dx.doi.org/10.1088/1361-6579/aae8a0
ISSN: 0967-3334
Appears in Collections:Dept of Mechanical Aerospace and Civil Engineering Research Papers

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