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DC Field | Value | Language |
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dc.contributor.author | Henry, MP | - |
dc.contributor.author | Hawkins, JR | - |
dc.contributor.author | Boyle, J | - |
dc.contributor.author | Bridger, JM | - |
dc.date.accessioned | 2018-12-04T14:18:34Z | - |
dc.date.available | 2018-12-04T14:18:34Z | - |
dc.date.issued | 2019-01-21 | - |
dc.identifier.citation | Henry, M.P., Hawkins, J.R., Boyle, J. and Bridger, J.M. (2019) 'The Genomic Health of Human Pluripotent Stem Cells: Genomic Instability and the Consequences on Nuclear Organization', Frontiers in Genomics 9:623, pp. 1-20. doi: 10.3389/fgene.2018.00623. | en_US |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/17179 | - |
dc.description.abstract | Human pluripotent stem cells (hPSC) are increasingly being used for cell-based regenerative therapies worldwide; with embryonic and induced pluripotent stem cells as potential treatments for debilitating and chronic conditions, such as age-related macular degeneration, Parkinsons disease, spinal cord injuries and type 1 diabetes. However, with the level of genomic anomalies stem cells generate in culture, their safety may be in question. Specifically, hPSCs frequently acquire chromosomal abnormalities, often with gains or losses of whole chromosomes. This review discusses how important it is to efficiently and sensitively detect hPSC aneuploidies, to understand how these aneuploidies arise, consider the consequences for the cell, and indeed the individual to which aneuploid cells may be administered. | en_US |
dc.description.sponsorship | National Institute for Biological Standards and Controls | en_US |
dc.format.medium | Electronic | - |
dc.language.iso | en | en_US |
dc.publisher | Frontiers Media | en_US |
dc.rights | Copyright © 2019 Henry, Hawkins, Boyle and Bridger. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | aneuploidy | en_US |
dc.subject | genome | en_US |
dc.subject | stem cell | en_US |
dc.subject | chromosome | en_US |
dc.subject | nucleus (positioning) | en_US |
dc.title | The Genomic Health of Human Pluripotent Stem Cells: Genomic Instability and the Consequences on Nuclear Organization | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.3389/fgene.2018.00623 | - |
dc.relation.isPartOf | Frontiers in Genetics | - |
pubs.publication-status | Published | - |
dc.identifier.eissn | 1664-8021 | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
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