Please use this identifier to cite or link to this item:
http://bura.brunel.ac.uk/handle/2438/17969
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Federico, C | - |
dc.contributor.author | Owoka, T | - |
dc.contributor.author | Ragusa, D | - |
dc.contributor.author | Sturiale, V | - |
dc.contributor.author | Caponnetto, D | - |
dc.contributor.author | Leotta, CG | - |
dc.contributor.author | Bruno, F | - |
dc.contributor.author | Foster, HA | - |
dc.contributor.author | Rigamonti, S | - |
dc.contributor.author | Giudici, G | - |
dc.contributor.author | Cazzaniga, G | - |
dc.contributor.author | Bridger, JM | - |
dc.contributor.author | Sisu, C | - |
dc.contributor.author | Saccone, S | - |
dc.contributor.author | Tosi, M | - |
dc.date.accessioned | 2019-04-30T10:28:19Z | - |
dc.date.available | 2019-04-30T10:28:19Z | - |
dc.date.issued | 2019-04-25 | - |
dc.identifier.citation | Federico, C., Owoka, T., Ragusa, D., Sturiale, V., Caponnetto, D., Leotta, C. G., Bruno, F., Foster, H. A., Rigamonti, S., Giudici, G., Cazzaniga, G., Bridger, J. M., Sisu, C., Saccone, S. and Tosi, S. (2019) ‘Deletions of Chromosome 7q Affect Nuclear Organization and HLXB9Gene Expression in Hematological Disorders’, Cancers, 11(4), 585, pp. 1-19. doi: 10.3390/cancers11040585. | en_US |
dc.identifier.other | 585 | - |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/17969 | - |
dc.description.abstract | © 2019 by the authors. The radial spatial positioning of individual gene loci within interphase nuclei has been associated with up- and downregulation of their expression. In cancer, the genome organization may become disturbed due to chromosomal abnormalities, such as translocations or deletions, resulting in the repositioning of genes and alteration of gene expression with oncogenic consequences. In this study, we analyzed the nuclear repositioning of HLXB9 (also called MNX1), mapping at 7q36.3, in patients with hematological disorders carrying interstitial deletions of 7q of various extents, with a distal breakpoint in 7q36. We observed that HLXB9 remains at the nuclear periphery, or is repositioned towards the nuclear interior, depending upon the compositional properties of the chromosomal regions involved in the rearrangement. For instance, a proximal breakpoint leading the guanine-cytosine (GC)-poor band 7q21 near 7q36 would bring HLXB9 to the nuclear periphery, whereas breakpoints that join the GC-rich band 7q22 to 7q36 would bring HLXB9 to the nuclear interior. This nuclear repositioning is associated with transcriptional changes, with HLXB9 in the nuclear interior becoming upregulated. Here we report an in cis rearrangement, involving one single chromosome altering gene behavior. Furthermore, we propose a mechanistic model for chromatin reorganization that affects gene expression via the influences of new chromatin neighborhoods. | en_US |
dc.description.sponsorship | This research was funded by Research Plan 2016n2018 from Department of Biological, Geological and Environmental Sciences, University of Catania to C.F.” and “The APC was funded by Brunel University London; V.S., and F.B. are supported by a fellowship of the PhD program (University of Catania, Italy); | en_US |
dc.format.extent | 1 - 19 | - |
dc.format.medium | Electronic | - |
dc.language.iso | en | en_US |
dc.publisher | MDPI | en_US |
dc.rights | © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | genome organization | en_US |
dc.subject | radial positioning | en_US |
dc.subject | chromosome deletion | en_US |
dc.subject | HLXB9 gene | en_US |
dc.subject | MNX1 gene | en_US |
dc.subject | chromosome 7 | en_US |
dc.title | Deletions of Chromosome 7q Affect Nuclear Organization and HLXB9Gene Expression in Hematological Disorders | en_US |
dc.title.alternative | Deletions of Chromosome 7q Affect Nuclear Organization and HLXB9 Gene Expression in Hematological Disorders | - |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.3390/cancers11040585 | - |
dc.relation.isPartOf | Cancers | - |
pubs.issue | 4 | - |
pubs.publication-status | Published | - |
pubs.volume | 11 | - |
dc.identifier.eissn | 2072-6694 | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
FullText.pdf | 8.53 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License