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http://bura.brunel.ac.uk/handle/2438/18492
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DC Field | Value | Language |
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dc.contributor.author | Tiller, NB | - |
dc.contributor.author | Chiesa, ST | - |
dc.contributor.author | Roberts, JD | - |
dc.contributor.author | Turner, LA | - |
dc.contributor.author | Jones, S | - |
dc.contributor.author | Romer, LM | - |
dc.date.accessioned | 2019-06-17T15:33:59Z | - |
dc.date.available | 2019-05-15 | - |
dc.date.available | 2019-06-17T15:33:59Z | - |
dc.date.issued | 2019-05-15 | - |
dc.identifier | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000467986400001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=f12c8c83318cf2733e615e54d9ed7ad5 | - |
dc.identifier | ARTN 589 | - |
dc.identifier | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000467986400001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=f12c8c83318cf2733e615e54d9ed7ad5 | - |
dc.identifier | ARTN 589 | - |
dc.identifier.citation | FRONTIERS IN PHYSIOLOGY, 2019, 10 pp. ? - ? (8) | en_US |
dc.identifier.issn | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000467986400001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=f12c8c83318cf2733e615e54d9ed7ad5 | - |
dc.identifier.issn | ARTN 589 | - |
dc.identifier.issn | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000467986400001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=f12c8c83318cf2733e615e54d9ed7ad5 | - |
dc.identifier.issn | ARTN 589 | - |
dc.identifier.issn | 1664-042X | - |
dc.identifier.issn | http://dx.doi.org/10.3389/fphys.2019.00589 | - |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/18492 | - |
dc.description.abstract | Background: This case-report characterized the respiratory, cardiovascular, and nutritional/gastrointestinal (GI) responses of a trained individual to a novel ultra-endurance exercise challenge. Case Presentation: A male athlete (age 45 years; V˙V˙O2max 54.0 mL⋅kg-1⋅min-1) summited 100 mountains on foot in 25 consecutive days (all elevations >600 m).Measures: Laboratory measures of pulmonary function (spirometry, whole-body plethysmography, and single-breath rebreathe), respiratory muscle function (maximum static mouth-pressures), and cardiovascular structure and function (echocardiography, electrocardiography, large vessel ultrasound, and flow-mediated dilatation) were made at baseline and 48 h post-challenge. Dietary intake (four-day food diary), self-reported GI symptoms and plasma endotoxin concentrations were assessed at baseline, pre/post mid-point, pre/post end-point, and 48 h post-challenge. Results: The challenge was completed in a total exercise time of 142 h (5.3 ± 2.8 h⋅d-1), with a distance of 1141 km (42.3 ± 43.9 km⋅d-1), and energy expenditure of 80460 kcal (2980 ± 1451 kcal⋅d-1). Relative to baseline, there were post-challenge decreases in pulmonary capacities and expiratory flows (≤34%), maximum expiratory mouth-pressure (19%), and maximum voluntary ventilation (29%). Heart rate variability deteriorated, manifesting as a 48% decrease in the root mean square of successive differences and a 70% increase in the low-frequency/high-frequency ratio. Pre- to post-challenge endotoxin concentrations were elevated by 60%, with a maximum increase of 130% after a given stage, congruent with an increased frequency and severity of GI symptoms.Conclusion: The challenge resulted in pulmonary and autonomic dysfunction, endotoxaemia, and GI distress. The findings extend our understanding of the limits of physiological function and may inform medical best-practice for personnel supporting ultra-endurance events. | en_US |
dc.format.extent | ? - ? (8) | - |
dc.language | English | - |
dc.language.iso | en | en_US |
dc.publisher | FRONTIERS MEDIA SA | en_US |
dc.subject | Science & Technology | en_US |
dc.subject | Life Sciences & Biomedicine | en_US |
dc.subject | Physiology | en_US |
dc.subject | cardiovascular | en_US |
dc.subject | nutrition | en_US |
dc.subject | respiratory | en_US |
dc.subject | ultra-endurance | en_US |
dc.subject | ultra-marathon | en_US |
dc.subject | RESPIRATORY MUSCLE FATIGUE | en_US |
dc.subject | FLOW-MEDIATED DILATION | en_US |
dc.subject | LUNG-FUNCTION | en_US |
dc.subject | STANDARDIZATION | en_US |
dc.subject | PREDICTION | en_US |
dc.subject | SOCIETY | en_US |
dc.subject | SPORTS | en_US |
dc.subject | IMPACT | en_US |
dc.subject | FOOD | en_US |
dc.title | Physiological and Pathophysiological Consequences of a 25-Day Ultra-Endurance Exercise Challenge | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.3389/fphys.2019.00589 | - |
dc.relation.isPartOf | FRONTIERS IN PHYSIOLOGY | - |
pubs.publication-status | Published | - |
pubs.volume | 10 | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
Files in This Item:
File | Description | Size | Format | |
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FullText.pdf | 361.96 kB | Adobe PDF | View/Open |
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