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http://bura.brunel.ac.uk/handle/2438/18851
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DC Field | Value | Language |
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dc.contributor.author | Huguet, F | - |
dc.contributor.author | Flynn, S | - |
dc.contributor.author | Vagnarelli, P | - |
dc.date.accessioned | 2019-07-24T10:16:27Z | - |
dc.date.available | 2019-07-24T10:16:27Z | - |
dc.date.issued | 2019-07-07 | - |
dc.identifier.citation | Cells, 8 (7), pp. 687 - 687 | en_US |
dc.identifier.issn | http://dx.doi.org/10.3390/cells8070687 | - |
dc.identifier.issn | 2073-4409 | - |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/18851 | - |
dc.description.abstract | The role of kinases in the regulation of cell cycle transitions is very well established, however, over the past decade, studies have identified the ever-growing importance of phosphatases in these processes. It is well-known that an intact or otherwise non-deformed nuclear envelope (NE) is essential for maintaining healthy cells and any deviation from this can result in pathological conditions. This review aims at assessing the current understanding of how phosphatases contribute to the remodelling of the nuclear envelope during its disassembling and reformation after cell division and how errors in this process may lead to the development of diseases.</jats:p> | en_US |
dc.description.sponsorship | The Wellcome Trust | en_US |
dc.format.extent | 687 - 687 | - |
dc.language | en | - |
dc.language.iso | en | en_US |
dc.publisher | MDPI AG | en_US |
dc.subject | Nuclear Envelope (NE) | en_US |
dc.subject | Nuclear Pore Complex (NPC) | en_US |
dc.subject | Nuclear Lamina | en_US |
dc.subject | Cyclin Dependent Kinase (CDK) | en_US |
dc.subject | Polo-like Kinase (PLK) | en_US |
dc.subject | Protein Phosphatase | en_US |
dc.subject | Micronuclei (MN) | en_US |
dc.title | The Role of Phosphatases in Nuclear Envelope Disassembly and Reassembly and Their Relevance to Pathologies | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.3390/cells8070687 | - |
dc.relation.isPartOf | Cells | - |
pubs.issue | 7 | - |
pubs.publication-status | Published online | - |
pubs.volume | 8 | - |
dc.identifier.eissn | 2073-4409 | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
Files in This Item:
File | Description | Size | Format | |
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FullText.pdf | 1.32 MB | Adobe PDF | View/Open |
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