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http://bura.brunel.ac.uk/handle/2438/18960Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Gupta, A | - |
| dc.contributor.author | Anjomani-Virmouni, S | - |
| dc.contributor.author | Koundouros, N | - |
| dc.contributor.author | Poulogiannis, G | - |
| dc.date.accessioned | 2019-08-15T14:09:58Z | - |
| dc.date.available | 2017-05-19 | - |
| dc.date.available | 2019-08-15T14:09:58Z | - |
| dc.date.issued | 2017-05-19 | - |
| dc.identifier.citation | Molecular and Cellular Oncology, 2017, 4 (6), pp. 1 - 2 | en_US |
| dc.identifier.issn | 2372-3556 | - |
| dc.identifier.issn | http://dx.doi.org/10.1080/23723556.2017.1329692 | - |
| dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/18960 | - |
| dc.description.abstract | Cancer and Parkinson disease (PD) derive from distinct alterations in cellular processes, yet there are pathogenic mutations that are unequivocally linked to both diseases. Here we expand on our recent findings that loss of parkin RBR E3 ubiquitin protein ligase (PRKN, best known as PARK2)—which is genetically linked to PD—promotes cancer progression via redox-mediated inactivation of phosphatase and tensin homolog (PTEN) by S-nitrosylation. | en_US |
| dc.description.sponsorship | Institute of Cancer Research, London | en_US |
| dc.format.extent | 1 - 2 | - |
| dc.language.iso | en | en_US |
| dc.publisher | Taylor & Francis | en_US |
| dc.subject | Cancer | en_US |
| dc.subject | Nitrosative stress | en_US |
| dc.subject | PARK2 | en_US |
| dc.subject | PTEN | en_US |
| dc.subject | S-nitrosylation | en_US |
| dc.title | PARK2 loss promotes cancer progression via redox-mediated inactivation of PTEN | en_US |
| dc.type | Article | en_US |
| dc.identifier.doi | http://dx.doi.org/10.1080/23723556.2017.1329692 | - |
| dc.relation.isPartOf | Molecular and Cellular Oncology | - |
| pubs.issue | 6 | - |
| pubs.publication-status | Published | - |
| pubs.volume | 4 | - |
| Appears in Collections: | Dept of Life Sciences Research Papers | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| FullText.pdf | 1.92 MB | Adobe PDF | View/Open |
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