Please use this identifier to cite or link to this item: http://bura.brunel.ac.uk/handle/2438/20584
Title: Using mathematical modelling to explore hypotheses about the role of bovine epithelium structure in foot-And-mouth disease virus-induced cell Lysis
Authors: Giorgakoudi, K
Gubbins, S
Ward, J
Juleff, N
Zhang, Z
Schley, D
Issue Date: 2-Oct-2015
Publisher: Public Library of Science
Citation: Giorgakoudi K, Gubbins S, Ward J, Juleff N, Zhang Z, Schley D (2015) Using Mathematical Modelling to Explore Hypotheses about the Role of Bovine Epithelium Structure in Foot-And-Mouth Disease Virus-Induced Cell Lysis. PLoS ONE 10(10): e0138571.
Abstract: Foot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals. FMD virus (FMDV) shows a strong tropism for epithelial cells, and FMD is characterised by cell lysis and the development of vesicular lesions in certain epithelial tissues (for example, the tongue). By contrast, other epithelial tissues do not develop lesions, despite being sites of viral replication (for example, the dorsal soft palate). The reasons for this difference are poorly understood, but hypotheses are difficult to test experimentally. In order to identify the factors which drive cell lysis, and consequently determine the development of lesions, we developed a partial differential equation model of FMDV infection in bovine epithelial tissues and used it to explore a range of hypotheses about epithelium structure which could be driving differences in lytic behaviour observed in different tissues. Our results demonstrate that, based on current parameter estimates, epithelial tissue thickness and cell layer structure are unlikely to be determinants of FMDV-induced cell lysis. However, differences in receptor distribution or viral replication amongst cell layers could influence the development of lesions, but only if viral replication rates are much lower than current estimates.
URI: http://bura.brunel.ac.uk/handle/2438/20584
DOI: http://dx.doi.org/10.1371/journal.pone.0138571
ISSN: 1932-6203
Appears in Collections:Dept of Clinical Sciences Research Papers

Files in This Item:
File Description SizeFormat 
FullText.pdf5.44 MBAdobe PDFView/Open


Items in BURA are protected by copyright, with all rights reserved, unless otherwise indicated.