Please use this identifier to cite or link to this item:
http://bura.brunel.ac.uk/handle/2438/21134
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sales Gil, R | - |
dc.contributor.author | Vagnarelli, P | - |
dc.date.accessioned | 2020-07-04T12:37:07Z | - |
dc.date.available | 2020-07-04T12:37:07Z | - |
dc.date.issued | 2020-06-12 | - |
dc.identifier | 1460 | - |
dc.identifier.citation | Sales-Gil, R. and Vagnarelli, P. (2020) 'How HP1 Post-Translational Modifications Regulate Heterochromatin Formation and Maintenance', Cells, 9 (6), 1460, pp. 1-13. doi: 10.3390/cells9061460. | en_US |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/21134 | - |
dc.description.abstract | Copyright © 2020 by the authors. Heterochromatin Protein 1 (HP1) is a highly conserved protein that has been used as a classic marker for heterochromatin. HP1 binds to di- and tri-methylated histone H3K9 and regulates heterochromatin formation, functions and structure. Besides the well-established phosphorylation of histone H3 Ser10 that has been shown to modulate HP1 binding to chromatin, several studies have recently highlighted the importance of HP1 post-translational modifications and additional epigenetic features for the modulation of HP1-chromatin binding ability and heterochromatin formation. In this review, we summarize the recent literature of HP1 post-translational modifications that have contributed to understand how heterochromatin is formed, regulated and maintained. | en_US |
dc.description.sponsorship | Wellcome Trust Investigator award | en_US |
dc.format.extent | 1 - 13 (13) | - |
dc.format.medium | Electronic | - |
dc.language | English | - |
dc.language.iso | en | en_US |
dc.publisher | MDPI | en_US |
dc.rights | Copyright © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | heterochromatin | en_US |
dc.subject | HP1 | en_US |
dc.subject | post-translational modifications | en_US |
dc.subject | centromeres | en_US |
dc.title | How HP1 post-translational modifications regulate heterochromatin formation and maintenance | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.3390/cells9061460 | - |
dc.relation.isPartOf | Cells | - |
pubs.issue | 6 | - |
pubs.publication-status | Published | - |
pubs.volume | 9 | - |
dc.identifier.eissn | 2073-4409 | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
FullText.pdf | 1.1 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License