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DC Field | Value | Language |
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dc.contributor.author | Capone, E | - |
dc.contributor.author | Lamolinara, A | - |
dc.contributor.author | Pastorino, F | - |
dc.contributor.author | Gentile, R | - |
dc.contributor.author | Ponziani, S | - |
dc.contributor.author | Di Vittorio, G | - |
dc.contributor.author | D’Agostino, D | - |
dc.contributor.author | Bibbò, S | - |
dc.contributor.author | Rossi, C | - |
dc.contributor.author | Piccolo, E | - |
dc.contributor.author | Iacobelli, V | - |
dc.contributor.author | Lattanzio, R | - |
dc.contributor.author | Panella, V | - |
dc.contributor.author | Sallese, M | - |
dc.contributor.author | De Laurenzi, V | - |
dc.contributor.author | Giansanti, F | - |
dc.contributor.author | Sala, A | - |
dc.contributor.author | Iezzi, M | - |
dc.contributor.author | Ponzoni, M | - |
dc.contributor.author | Ippoliti, R | - |
dc.contributor.author | Iacobelli, S | - |
dc.contributor.author | Sala, G | - |
dc.date.accessioned | 2020-10-29T12:40:16Z | - |
dc.date.available | 2020-10-29T12:40:16Z | - |
dc.date.issued | 2020-10-15 | - |
dc.identifier | 2989 | - |
dc.identifier.citation | Capone, E., Lamolinara, A., Pastorino, F., Gentile, R., Ponziani, S., Di Vittorio, G., D’Agostino, D., Bibbò, S., Rossi, C., Piccolo, E., Iacobelli, V., Lattanzio, R., Panella, V., Sallese, M., De Laurenzi, V., Giansanti, F., Sala, A., Iezzi, M., Ponzoni, M., Ippoliti, R., Iacobelli, S. and Sala, G. (2020) ‘Targeting Vesicular LGALS3BP by an Antibody-Drug Conjugate as Novel Therapeutic Strategy for Neuroblastoma’, Cancers, 12(10), 2989. pp. 1-18. doi: 10.3390/cancers12102989. | en_US |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/21742 | - |
dc.description.abstract | Copyright © 2020 by the authors. Neuroblastoma is the most common extra-cranial solid tumor in infants and children, which accounts for approximately 15% of all cancer-related deaths in the pediatric population. New therapeutic modalities are urgently needed. Antibody-Drug Conjugates (ADC)s-based therapy has been proposed as potential strategy to treat this pediatric malignancy. LGALS3BP is a highly glycosylated protein involved in tumor growth and progression. Studies have shown that LGALS3BP is enriched in extracellular vesicles (EV)s derived by most neuroblastoma cells, where it plays a critical role in preparing a favorable tumor microenvironment (TME) through direct cross talk between cancer and stroma cells. Here, we describe the development of a non-internalizing LGALS3BP ADC, named 1959-sss/DM3, which selectively targets LGALS3BP expressing neuroblastoma. 1959-sss/DM3 mediated potent therapeutic activity in different types of neuroblastoma models. Notably, we found that treatments were well tolerated at efficacious doses that were fully curative. These results offer preclinical proof-of-concept for an ADC targeting exosomal LGALS3BP approach for neuroblastomas. | en_US |
dc.description.sponsorship | This work was partially supported by Mediapharma Srl. G.S. and V.D.L. are supported by AIRC (IG:18467; IG 20043). A.S. and S.B. are supported by Fondazione Italiana per la Lotta al Neuroblastoma” to A.S. | en_US |
dc.format.extent | 1 - 18 | - |
dc.format.medium | Electronic | - |
dc.language.iso | en | en_US |
dc.publisher | MDPI AG | en_US |
dc.rights | Copyright © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | Antibody-Drug Conjugates (ADC)s | en_US |
dc.subject | LGALS3BP | en_US |
dc.subject | neuroblastoma | en_US |
dc.subject | targeted therapy | en_US |
dc.title | Targeting Vesicular LGALS3BP by an Antibody-Drug Conjugate as Novel Therapeutic Strategy for Neuroblastoma | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.3390/cancers12102989 | - |
dc.relation.isPartOf | Cancers | - |
pubs.issue | 10 | - |
pubs.publication-status | Published online | - |
pubs.volume | 12 | - |
dc.identifier.eissn | 2072-6694 | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
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