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DC Field | Value | Language |
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dc.contributor.author | Evangelou, E | - |
dc.contributor.author | Suzuki, H | - |
dc.contributor.author | Bai, W | - |
dc.contributor.author | Pazoki, R | - |
dc.contributor.author | Gao, H | - |
dc.contributor.author | Matthews, PM | - |
dc.contributor.author | Elliott, P | - |
dc.date.accessioned | 2021-08-01T19:08:47Z | - |
dc.date.available | 2021-08-01T19:08:47Z | - |
dc.date.issued | 2021-06-01 | - |
dc.identifier | e65325 | - |
dc.identifier.citation | Evangelou, E., Suzuki, H., Bai, W., Pazoki, R., Gao, H., Matthews, P.M. and Elliott, P. (2021) 'Alcohol consumption in the general population is associated with structural changes in multiple organ systems', eLife 10, e65325, pp. 1-15. doi: 10.7554/eLife.65325. | en_US |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/23038 | - |
dc.description.abstract | Copyright © 2021 Evangelou et al. Background: Excessive alcohol consumption is associated with damage to various organs, but its multi-organ effects have not been characterised across the usual range of alcohol drinking in a large general population sample. Methods: We assessed global effect sizes of alcohol consumption on quantitative magnetic resonance imaging phenotypic measures of the brain, heart, aorta, and liver of UK Biobank participants who reported drinking alcohol. Results: We found a monotonic association of higher alcohol consumption with lower normalised brain volume across the range of alcohol intakes (–1.7 ☓ 103 ± 0.76 ☓ 103 per doubling of alcohol consumption, p=3.0 ☓ 1014 ). Alcohol consumption was also associated directly with measures of left ventricular mass index and left ventricular and atrial volume indices. Liver fat increased by a mean of 0.15% per doubling of alcohol consumption. Conclusions: Our results imply that there is not a ‘safe threshold’ below which there are no toxic effects of alcohol. Current public health guidelines concerning alcohol consumption may need to be revisited. | en_US |
dc.description.sponsorship | Medical Research Council (MR/R0265051/1); Medical Research Council (MR/R0265051/2); Medical Research Council (MR/L01341X/1); British Heart Foundation (RE/18/4/34215); Medical Research Council (MR/S019669/1); Japan Society for the Promotion of Science (20K07776). | en_US |
dc.format.extent | 1 - 15 | - |
dc.format.medium | Electronic | - |
dc.language.iso | en_US | en_US |
dc.publisher | eLife Sciences Publications | en_US |
dc.rights | Copyright © 2021Evangelou et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.title | Alcohol consumption in the general population is associated with structural changes in multiple organ systems | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.7554/eLife.65325 | - |
dc.relation.isPartOf | eLife | - |
pubs.publication-status | Published | - |
pubs.volume | 10 | - |
dc.identifier.eissn | 2050-084X | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
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