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DC Field | Value | Language |
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dc.contributor.author | Osório, L | - |
dc.contributor.author | Silva, E | - |
dc.contributor.author | Mackay, R | - |
dc.date.accessioned | 2021-08-26T05:31:28Z | - |
dc.date.available | 2021-08-26T05:31:28Z | - |
dc.date.issued | 2021-08-06 | - |
dc.identifier | 113 | - |
dc.identifier.citation | Osório, L. A., Silva, E. and Mackay, R. E. (2021) ‘A Review of Biomaterials and Scaffold Fabrication for Organ-on-a-Chip (OOAC) Systems’, Bioengineering, 8(8), 113, p. 1-.31 doi: 10.3390/bioengineering8080113. | en_US |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/23118 | - |
dc.description.abstract | Copyright: © 2021 by the authors. Drug and chemical development along with safety tests rely on the use of numerous clinical models. This is a lengthy process where animal testing is used as a standard for pre-clinical trials. However, these models often fail to represent human physiopathology. This may lead to poor correlation with results from later human clinical trials. Organ-on-a-Chip (OOAC) systems are engineered microfluidic systems, which recapitulate the physiochemical environment of a specific organ by emulating the perfusion and shear stress cellular tissue undergoes in vivo and could replace current animal models. The success of culturing cells and cell-derived tissues within these systems is dependent on the scaffold chosen; hence, scaffolds are critical for the success of OOACs in research. A literature review was conducted looking at current OOAC systems to assess the advantages and disadvantages of different materials and manufacturing techniques used for scaffold production; and the alternatives that could be tailored from the macro tissue engineering research field. | en_US |
dc.description.sponsorship | EPSRC studentship. | en_US |
dc.format.extent | 1 - 31 | - |
dc.format.medium | Electronic | - |
dc.language.iso | en_US | en_US |
dc.publisher | MDPI | en_US |
dc.rights | Copyright: © 2021 by the authors. Submitted for possible open accesspublication under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | organ-on-a-chip | en_US |
dc.subject | scaffold | en_US |
dc.subject | tissue engineering | en_US |
dc.subject | biomaterials | en_US |
dc.subject | additive manufacturing | en_US |
dc.title | A Review of Biomaterials and Scaffold Fabrication for Organ-on-a-Chip (OOAC) Systems | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.3390/bioengineering8080113 | - |
dc.relation.isPartOf | Bioengineering | - |
pubs.issue | 8 | - |
pubs.publication-status | Published | - |
pubs.volume | 8 | - |
dc.identifier.eissn | 2306-5354 | - |
Appears in Collections: | Dept of Life Sciences Research Papers Dept of Mechanical and Aerospace Engineering Research Papers |
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