Please use this identifier to cite or link to this item:
http://bura.brunel.ac.uk/handle/2438/23339
Title: | Variation at the Klotho gene locus does not affect cognitive function in up to 335,074 British Caucasians in the UK Biobank |
Authors: | Amin, HA Drenos, F Blakemore, AI |
Issue Date: | 15-Nov-2019 |
Publisher: | Cold Spring Harbor Laboratory |
Citation: | Amin, H.A., Drenos, F. and Blakemore, A.I. (2019) 'Variation at the Klotho gene locus does not affect cognitive function in up to 335,074 British Caucasians in the UK Biobank', bioRxiv, 838409, pp. 1 - 24. doi: 10.1101/838409. |
Abstract: | Copyright © The Author(s)/Funder. The proportion of older adults in Western populations is increasing and there is, therefore, a need to define factors affecting maintenance of physical and cognitive health in old age. Variations in the Klotho (KL) gene, and specifically the KL-VS haplotype, have been identified by several authors as potentially influencing cognitive function and decline. We have attempted to verify the reported associations between KL variants, including the KL-VS haplotype, and cognitive function in up to 335,074 British Caucasian participants aged 40-79 years from the UK Biobank. We do not find evidence that KL-VS affects cognitive function or its decline with increasing age. We examined a further 244 KL variants and found that rs117650866 was associated with Prospective Memory, but could not replicate this in follow-up samples. In conclusion, there is insufficient evidence in the UK Biobank to support the concept that KL variants affect cognitive function or its rate of decline. |
Description: | Version 2 issued 19 November 2019. |
URI: | https://bura.brunel.ac.uk/handle/2438/23339 |
DOI: | https://doi.org/10.1101/838409 |
Other Identifiers: | 838409 |
Appears in Collections: | Dept of Life Sciences Research Papers |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Pre-print.pdf | 885.82 kB | Adobe PDF | View/Open |
Items in BURA are protected by copyright, with all rights reserved, unless otherwise indicated.