Please use this identifier to cite or link to this item:
http://bura.brunel.ac.uk/handle/2438/23848
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ansari, J | - |
dc.contributor.author | Gavins, FNE | - |
dc.date.accessioned | 2021-12-30T18:28:09Z | - |
dc.date.available | 2021-12-30T18:28:09Z | - |
dc.date.issued | 2021-12-19 | - |
dc.identifier | 1945 | - |
dc.identifier.citation | Ansari, J. and Gavins, F.N.E. (2021) ‘Neutrophils and Platelets: Immune Soldiers Fighting Together in Stroke Pathophysiology’, Biomedicines, 9 (12), 1945, pp. 1-13. doi: 10.3390/biomedicines9121945. | en_US |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/23848 | - |
dc.description.abstract | Copyright: © 2021 by the authors. Neutrophils and platelets exhibit a diverse repertoire of functions in thromboinflammatory conditions such as stroke. Most cerebral ischemic events result from longstanding chronic inflammation secondary to underlying pathogenic conditions, e.g., hypertension, diabetes mellitus, obstructive sleep apnea, coronary artery disease, atrial fibrillation, morbid obesity, dyslipidemia, and sickle cell disease. Neutrophils can enable, as well as resolve, cerebrovascular inflammation via many effector functions including neutrophil extracellular traps, serine proteases and reactive oxygen species, and pro-resolving endogenous molecules such as Annexin A1. Like neutrophils, platelets also engage in pro- as well as anti-inflammatory roles in regulating cerebrovascular inflammation. These anucleated cells are at the core of stroke pathogenesis and can trigger an ischemic event via adherence to the hypoxic cerebral endothelial cells culminating in aggregation and clot formation. In this article, we review and highlight the evolving role of neutrophils and platelets in ischemic stroke and discuss ongoing preclinical and clinical strategies that may produce viable therapeutics for prevention and management of stroke. | en_US |
dc.format.extent | 1 - 13 | - |
dc.format.medium | Electronic | - |
dc.language.iso | en_US | en_US |
dc.publisher | MDPI AG | en_US |
dc.rights | Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | neutrophils | en_US |
dc.subject | platelets | en_US |
dc.subject | stroke | en_US |
dc.subject | annexin A1 | en_US |
dc.subject | resolution | en_US |
dc.subject | thromboinflammation | en_US |
dc.title | Neutrophils and Platelets: Immune Soldiers Fighting Together in Stroke Pathophysiology | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.3390/biomedicines9121945 | - |
dc.relation.isPartOf | Biomedicines | - |
pubs.issue | 12 | - |
pubs.publication-status | Published online | - |
pubs.volume | 9 | - |
dc.identifier.eissn | 2227-9059 | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
FullText.pdf | 2.29 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License