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Title: | Invited Perspective: How Relevant Are Mode-of-Action Considerations for the Assessment and Prediction of Mixture Effects? |
Authors: | Kortenkamp, A |
Issue Date: | 8-Apr-2022 |
Publisher: | National Institute of Environmental Health Sciences (NIEHS) |
Citation: | Kortenkamp, A. (2022) ‘Invited Perspective: How Relevant Are Mode-of-Action Considerations for the Assessment and Prediction of Mixture Effects?’, Environmental Health Perspectives. Environmental Health Perspectives. doi:10.1289/ehp11051. |
Abstract: | Distinguishing chemical mixtures in terms of the similarity vs. dissimilarity of their components’ mechanisms or modes of action (MOAs) is perceived as a key issue in mixture risk assessment. However, the well-designed study by Van der Ven et al.1 of a mixture of chemicals producing craniofacial malformations in zebra fish embryos calls the relevance of such distinctions into question |
Description: | This article is a companion of: Van Der Ven, L.T.M. et al. (2022) ‘Dose Addition in the Induction of Craniofacial Malformations in Zebrafish Embryos Exposed to a Complex Mixture of Food-Relevant Chemicals with Dissimilar Modes of Action’, Environmental Health Perspectives. Environmental Health Perspectives. doi:10.1289/ehp9888. |
URI: | http://bura.brunel.ac.uk/handle/2438/24499 |
DOI: | http://dx.doi.org/10.1289/EHP11051 |
ISSN: | 0091-6765 1552-9924 |
Appears in Collections: | Dept of Life Sciences Research Papers |
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