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dc.contributor.authorStanford, GE-
dc.contributor.authorJones, M-
dc.contributor.authorCharman, SC-
dc.contributor.authorBilton, D-
dc.contributor.authorUsmani, OS-
dc.contributor.authorDavies, JC-
dc.contributor.authorSimmonds, NJ-
dc.identifier.citationStanford, G.E. et al. (2022) Clinimetric analysis of outcome measures for airway clearance in people with cystic fibrosis: a systematic review'', Therapeutic Advances in Respiratory Disease, 16, pp. 1 - 12. dpo: /10.1177/17534666221122572.en_US
dc.descriptionAvailability of data and materials: The data sets used and/or analysed during the current study are available from the corresponding author on reasonable request. The search strategy for OVID has been provided in the supplementary material.en_US
dc.description.abstractCopyright © The Author(s), 2022. Background: Airway clearance techniques (ACTs) are integral to cystic fibrosis (CF) management. However, there is no consensus as to which outcome measures (OMs) are best for assessing ACT efficacy. Objectives: To summarise OMs that have been assessed for their clinimetric properties (including validity, feasibility, reliability, and reproducibility) within the context of ACT research in CF. Design and Methods: A systematic review was conducted according to Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA) standards. Any parallel or cross-over randomised controlled trial (RCT) investigating outcome measures for ACT in the CF population were eligible for inclusion. The search was performed in five medical databases,, and abstracts from international CF conferences. The authors planned to independently assess study quality and risk of bias using the COnsensus-based Standards for the selection of health status Measurement InstrumeNts (COSMIN) risk of bias checklist with external validity assessment based upon study details (participants and study intervention). Two review authors (GS and MJ) independently screened search results against inclusion criteria, and further data extraction were planned but not required. Results: No completed RCTs from the 187 studies identified met inclusion criteria for the primary or post hoc secondary objective. Two ongoing trials were identified. Discussion and conclusion: This empty systematic review highlights that high-quality RCTs are urgently needed to investigate and validate the clinimetric properties of OMs used to assess ACT efficacy. With the changing demographics of CF combined with the introduction of cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapies, an accurate assessment of the current benefit of ACT or the effect of ACT withdrawal is a high priority for clinical practice and future research; OMs which have been validated for this purpose are essential. Registration: This systematic review was registered on the PROSPERO database (CRD42020206033).en_US
dc.description.sponsorshipNIHR Clinical Doctoral Fellowship grant for GS (reference CDRF-2014-05-055).en_US
dc.format.extent1 - 12-
dc.publisherSAGE Publicationsen_US
dc.rightsCopyright © The Author(s), 2022. Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License ( which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (
dc.subjectairway clearanceen_US
dc.subjectcystic fibrosisen_US
dc.subjectoutcome measuresen_US
dc.titleClinimetric analysis of outcome measures for airway clearance in people with cystic fibrosis: a systematic reviewen_US
dc.relation.isPartOfTherapeutic Advances in Respiratory Disease-
dc.rights.holderThe Author(s)-
Appears in Collections:Dept of Clinical Sciences Research Papers

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