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DC Field | Value | Language |
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dc.contributor.author | Valls, PO | - |
dc.contributor.author | Esposito, A | - |
dc.date.accessioned | 2022-10-26T10:54:42Z | - |
dc.date.available | 2022-04-01 | - |
dc.date.available | 2022-10-26T10:54:42Z | - |
dc.date.issued | 2022-03-01 | - |
dc.identifier | 102066 | - |
dc.identifier | ORCiD ID: Alessandro Esposito - https://orcid.org/0000-0002-5051-091X | - |
dc.identifier.citation | Valls, P.O. and Esposito, A. (2022) 'Signalling dynamics, cell decisions, and homeostatic control in health and disease', Current Opinion in Cell Biology, 75, 102066, pp. 1 - 9. doi: 10.1016/j.ceb.2022.01.011. | en_US |
dc.identifier.issn | 0955-0674 | - |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/25374 | - |
dc.description.abstract | Copyright © 2022 The Authors.. Cell signalling engenders cells with the capability to receive and process information from the intracellular and extracellular environments, trigger and execute biological responses, and communicate with each other. Ultimately, cell signalling is responsible for maintaining homeostasis at the cellular, tissue and systemic level. For this reason, cell signalling is a topic of intense research efforts aimed to elucidate how cells coordinate transitions between states in developing and adult organisms in physiological and pathological conditions. Here, we review current knowledge of how cell signalling operates at multiple spatial and temporal scales, focusing on how single-cell analytical techniques reveal mechanisms underpinning cell-to-cell variability, signalling plasticity, and collective cellular responses. | en_US |
dc.description.sponsorship | CRUK multi-disciplinary project award (OncoLive, C54674/A27487), pump-priming funds from the CRUK Cambridge Center (C9685/A25117, C9685/A28397); Medical Research Council program grants (MC_UU_12022/1 and MC_UU_12022/8) awarded to the MRC Cancer Unit; MRC Doctoral Training Award (ref. 1753414) granted to the MRC Cancer Unit. | en_US |
dc.format.extent | 1 - 9 | - |
dc.format.medium | Print-Electronic | - |
dc.language | English | - |
dc.language.iso | en_US | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | Copyright © 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (https://creativecommons.org/licenses/by/4.0/). | - |
dc.title | Signalling dynamics, cell decisions, and homeostatic control in health and disease | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.1016/j.ceb.2022.01.011 | - |
dc.relation.isPartOf | Current Opinion in Cell Biology | - |
pubs.publication-status | Published | - |
pubs.volume | 75 | - |
dc.identifier.eissn | 1879-0410 | - |
dc.rights.holder | The Authors | - |
dc.rights.holder | https://creativecommons.org/licenses/by/4.0/ | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
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FullText.pdf | 1.54 MB | Adobe PDF | View/Open |
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