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DC Field | Value | Language |
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dc.contributor.author | Dake, MD | - |
dc.contributor.author | De Marco, M | - |
dc.contributor.author | Blackburn, DJ | - |
dc.contributor.author | Wilkinson, ID | - |
dc.contributor.author | Remes, A | - |
dc.contributor.author | Liu, Y | - |
dc.contributor.author | Pikkarainen, M | - |
dc.contributor.author | Hallikainen, M | - |
dc.contributor.author | Soininen, H | - |
dc.contributor.author | Venneri, A | - |
dc.date.accessioned | 2022-10-31T17:45:11Z | - |
dc.date.available | 2022-10-31T17:45:11Z | - |
dc.date.issued | 2021-01-20 | - |
dc.identifier.citation | Dake, M.D. et al. (2021) 'Obesity and Brain Vulnerability in Normal and Abnormal Aging: A Multimodal MRI Study', Journal of Alzheimer's Disease Reports, 5 (1), pp. 65 - 77. doi: 10.3233/ADR-200267. | en_US |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/25406 | - |
dc.description.abstract | Copyright © 2021– The authors. Background: How the relationship between obesity and MRI-defined neural properties varies across distinct stages of cognitive impairment due to Alzheimer’s disease is unclear. Objective: We used multimodal neuroimaging to clarify this relationship. Methods: Scans were acquired from 47 patients clinically diagnosed with mild Alzheimer’s disease dementia, 68 patients with mild cognitive impairment, and 57 cognitively healthy individuals. Voxel-wise associations were run between maps of gray matter volume, white matter integrity, and cerebral blood flow, and global/visceral obesity. Results: Negative associations were found in cognitively healthy individuals between obesity and white matter integrity and cerebral blood flow of temporo-parietal regions. In mild cognitive impairment, negative associations emerged in frontal, temporal, and brainstem regions. In mild dementia, a positive association was found between obesity and gray matter volume around the right temporoparietal junction. Conclusion: Obesity might contribute toward neural tissue vulnerability in cognitively healthy individuals and mild cognitive impairment, while a healthy weight in mild Alzheimer’s disease dementia could help preserve brain structure in the presence of age and disease-related weight loss. | en_US |
dc.description.sponsorship | European Union Seventh Framework Programme (FP7/2007– 2013) under grant agreement no. 601055, VPH-DARE@IT; Neurocare; University of Sheffield, Faculty of Medicine, Dentistry and Health PhD scholarship. | en_US |
dc.format.extent | 65 - 77 | - |
dc.format.medium | Electronic | - |
dc.language | English | - |
dc.language.iso | en_US | en_US |
dc.publisher | IOS Press | en_US |
dc.rights | Copyright © 2021– The authors. Published by IOS Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC 4.0). | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | - |
dc.subject | Alzheimer’s disease | en_US |
dc.subject | body mass index | en_US |
dc.subject | neuroimaging | en_US |
dc.subject | overweight | en_US |
dc.title | Obesity and Brain Vulnerability in Normal and Abnormal Aging: A Multimodal MRI Study | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.3233/ADR-200267 | - |
dc.relation.isPartOf | Journal of Alzheimer's Disease Reports | - |
pubs.issue | 1 | - |
pubs.publication-status | Published | - |
pubs.volume | 5 | - |
dc.identifier.eissn | 2542-4823 | - |
dc.rights.holder | The authors | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
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FullText.pdf | Copyright © 2021– The authors. Published by IOS Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC 4.0). | 663.45 kB | Adobe PDF | View/Open |
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