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DC Field | Value | Language |
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dc.contributor.author | Pezzoli, S | - |
dc.contributor.author | De Marco, M | - |
dc.contributor.author | Zorzi, G | - |
dc.contributor.author | Cagnin, A | - |
dc.contributor.author | Venneri, A | - |
dc.date.accessioned | 2022-10-31T18:03:21Z | - |
dc.date.available | 2022-10-31T18:03:21Z | - |
dc.date.issued | 2021-04-29 | - |
dc.identifier.citation | Pezzoli, S. et al. (2021) 'Functional Brain Connectivity Patterns Associated with Visual Hallucinations in Dementia with Lewy Bodies', Journal of Alzheimer's Disease Reports, 5 (1), pp. 311 - 320. doi: 10.3233/ADR-200288. | en_US |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/25407 | - |
dc.description | The supplementary material is available in the electronic version of this article: https://doi.org/ 10.3233/ADR-200288. | en_US |
dc.description.abstract | Copyright © 2021 – The authors. Background: The presence of recurrent, complex visual hallucinations (VH) is among the core clinical features of dementia with Lewy bodies (DLB). It has been proposed that VH arise from a disrupted organization of functional brain networks. However, studies are still limited, especially investigating the resting-state functional brain features underpinning VH in patients with dementia. Objective: The aim of the present pilot study was to investigate whether there were any alterations in functional connectivity associated with VH in DLB. Methods: Seed-based analyses and independent component analysis (ICA) of resting-state fMRI scans were carried out to explore differences in functional connectivity between DLB patients with and without VH. Results: Seed-based analyses reported decreased connectivity of the lateral geniculate nucleus, the superior parietal lobule and the putamen with the medial frontal gyrus in DLB patients with VH. Visual areas showed a pattern of both decreased and increased functional connectivity. ICA revealed between-group differences in the default mode network (DMN). Conclusion: Functional connectivity analyses suggest dysfunctional top-down and bottom-up processes and DMN-related alterations in DLB patients with VH. This impairment might foster the generation of false visual images that are misinterpreted, ultimately resulting in VH. | en_US |
dc.description.sponsorship | Faculty of Medicine, Dentistry and Health, University of Sheffield, UK matched funding studentship. | en_US |
dc.format.extent | 311 - 320 | - |
dc.format.medium | Electronic | - |
dc.language | English | - |
dc.language.iso | en_US | en_US |
dc.publisher | IOS Press | en_US |
dc.rights | Copyright © 2021 – The authors. Published by IOS Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC 4.0). | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | - |
dc.subject | dementia with Lewy bodies | en_US |
dc.subject | functional connectivity | en_US |
dc.subject | resting-state fMRI | en_US |
dc.subject | resting-state networks | en_US |
dc.subject | visual hallucinations | en_US |
dc.title | Functional Brain Connectivity Patterns Associated with Visual Hallucinations in Dementia with Lewy Bodies | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.3233/ADR-200288 | - |
dc.relation.isPartOf | Journal of Alzheimer's Disease Reports | - |
pubs.issue | 1 | - |
pubs.publication-status | Published | - |
pubs.volume | 5 | - |
dc.identifier.eissn | 2542-4823 | - |
dc.rights.holder | The authors | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
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FullText.pdf | Copyright © 2021 – The authors. Published by IOS Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC 4.0). | 988.37 kB | Adobe PDF | View/Open |
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