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DC Field | Value | Language |
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dc.contributor.author | Evans, RA | - |
dc.contributor.author | Leavy, OC | - |
dc.contributor.author | Richardson, M | - |
dc.contributor.author | Elneima, O | - |
dc.contributor.author | McAuley, HJC | - |
dc.contributor.author | Shikotra, A | - |
dc.contributor.author | Singapuri, A | - |
dc.contributor.author | Sereno, M | - |
dc.contributor.author | Saunders, RM | - |
dc.contributor.author | Harris, VC | - |
dc.contributor.author | Houchen-Wolloff, L | - |
dc.contributor.author | Aul, R | - |
dc.contributor.author | Beirne, P | - |
dc.contributor.author | Bolton, CE | - |
dc.contributor.author | Brown, JS | - |
dc.contributor.author | Choudhury, G | - |
dc.contributor.author | Diar-Bakerly, N | - |
dc.contributor.author | Easom, N | - |
dc.contributor.author | Echevarria, C | - |
dc.contributor.author | Fuld, J | - |
dc.contributor.author | Hart, N | - |
dc.contributor.author | Hurst, J | - |
dc.contributor.author | Jones, MG | - |
dc.contributor.author | Parekh, D | - |
dc.contributor.author | Pfeffer, P | - |
dc.contributor.author | Rahman, NM | - |
dc.contributor.author | Rowland-Jones, SL | - |
dc.contributor.author | Shah, AM | - |
dc.contributor.author | Wootton, DG | - |
dc.contributor.author | Chalder, T | - |
dc.contributor.author | Davies, MJ | - |
dc.contributor.author | De Soyza, A | - |
dc.contributor.author | Geddes, JR | - |
dc.contributor.author | Greenhalf, W | - |
dc.contributor.author | Greening, NJ | - |
dc.contributor.author | Heaney, LG | - |
dc.contributor.author | Heller, S | - |
dc.contributor.author | Howard, LS | - |
dc.contributor.author | Jacob, J | - |
dc.contributor.author | Jenkins, RG | - |
dc.contributor.author | Lord, JM | - |
dc.contributor.author | Man, WDC | - |
dc.contributor.author | McCann, GP | - |
dc.contributor.author | Neubauer, S | - |
dc.contributor.author | Openshaw, PJM | - |
dc.contributor.author | Porter, JC | - |
dc.contributor.author | Rowland, MJ | - |
dc.contributor.author | Scott, JT | - |
dc.contributor.author | Semple, MG | - |
dc.contributor.author | Singh, SJ | - |
dc.contributor.author | Thomas, DC | - |
dc.contributor.author | Toshner, M | - |
dc.contributor.author | Lewis, KE | - |
dc.contributor.author | Thwaites, RS | - |
dc.contributor.author | Briggs, A | - |
dc.contributor.author | Docherty, AB | - |
dc.contributor.author | Kerr, S | - |
dc.contributor.author | Lone, NI | - |
dc.contributor.author | Quint, J | - |
dc.contributor.author | Sheikh, A | - |
dc.contributor.author | Thorpe, M | - |
dc.contributor.author | Zheng, B | - |
dc.contributor.author | Chalmers, JD | - |
dc.contributor.author | Ho, LP | - |
dc.contributor.author | Horsley, A | - |
dc.contributor.author | Marks, M | - |
dc.contributor.author | Poinasamy, K | - |
dc.contributor.author | Raman, B | - |
dc.contributor.author | Harrison, EM | - |
dc.contributor.author | Wain, LV | - |
dc.contributor.author | Brightling, CE | - |
dc.contributor.author | Abel, K | - |
dc.contributor.author | Adamali, H | - |
dc.contributor.author | Adeloye, D | - |
dc.contributor.author | Adeyemi, O | - |
dc.contributor.author | Adrego, R | - |
dc.contributor.author | Aguilar Jimenez, LA | - |
dc.contributor.author | Ahmad, S | - |
dc.contributor.author | Ahmad Haider, N | - |
dc.contributor.author | Ahmed, R | - |
dc.contributor.author | Ahwireng, N | - |
dc.contributor.author | Ainsworth, M | - |
dc.contributor.author | Al-Sheklly, B | - |
dc.contributor.author | Alamoudi, A | - |
dc.contributor.author | Ali, M | - |
dc.contributor.author | Aljaroof, M | - |
dc.contributor.author | All, AM | - |
dc.contributor.author | Allan, L | - |
dc.contributor.author | Allen, RJ | - |
dc.contributor.author | Allerton, L | - |
dc.contributor.author | Allsop, L | - |
dc.contributor.author | Almeida, P | - |
dc.contributor.author | Altmann, D | - |
dc.contributor.author | Alvarez Corral, M | - |
dc.contributor.author | Amoils, S | - |
dc.contributor.author | Anderson, D | - |
dc.contributor.author | Antoniades, C | - |
dc.contributor.author | Arbane, G | - |
dc.contributor.author | Arias, A | - |
dc.contributor.author | Armour, C | - |
dc.date.accessioned | 2022-11-23T16:49:07Z | - |
dc.date.available | 2022-11-23T16:49:07Z | - |
dc.date.issued | 2022-08-01 | - |
dc.identifier.citation | Evans, R.A. et al. (2022) ‘Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study’ in The Lancet Respiratory Medicine, 10 (8), pp. 761 - 775. doi: 10.1016/s2213-2600(22)00127-8. | en_US |
dc.identifier.issn | 2213-2600 | - |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/25532 | - |
dc.description.abstract | Copyright © 2022 The Author(s). Background: No effective pharmacological or non-pharmacological interventions exist for patients with long COVID. We aimed to describe recovery 1 year after hospital discharge for COVID-19, identify factors associated with patient-perceived recovery, and identify potential therapeutic targets by describing the underlying inflammatory profiles of the previously described recovery clusters at 5 months after hospital discharge. Methods: The Post-hospitalisation COVID-19 study (PHOSP-COVID) is a prospective, longitudinal cohort study recruiting adults (aged ≥18 years) discharged from hospital with COVID-19 across the UK. Recovery was assessed using patient-reported outcome measures, physical performance, and organ function at 5 months and 1 year after hospital discharge, and stratified by both patient-perceived recovery and recovery cluster. Hierarchical logistic regression modelling was performed for patient-perceived recovery at 1 year. Cluster analysis was done using the clustering large applications k-medoids approach using clinical outcomes at 5 months. Inflammatory protein profiling was analysed from plasma at the 5-month visit. This study is registered on the ISRCTN Registry, ISRCTN10980107, and recruitment is ongoing. Findings: 2320 participants discharged from hospital between March 7, 2020, and April 18, 2021, were assessed at 5 months after discharge and 807 (32·7%) participants completed both the 5-month and 1-year visits. 279 (35·6%) of these 807 patients were women and 505 (64·4%) were men, with a mean age of 58·7 (SD 12·5) years, and 224 (27·8%) had received invasive mechanical ventilation (WHO class 7–9). The proportion of patients reporting full recovery was unchanged between 5 months (501 [25·5%] of 1965) and 1 year (232 [28·9%] of 804). Factors associated with being less likely to report full recovery at 1 year were female sex (odds ratio 0·68 [95% CI 0·46–0·99]), obesity (0·50 [0·34–0·74]) and invasive mechanical ventilation (0·42 [0·23–0·76]). Cluster analysis (n=1636) corroborated the previously reported four clusters: very severe, severe, moderate with cognitive impairment, and mild, relating to the severity of physical health, mental health, and cognitive impairment at 5 months. We found increased inflammatory mediators of tissue damage and repair in both the very severe and the moderate with cognitive impairment clusters compared with the mild cluster, including IL-6 concentration, which was increased in both comparisons (n=626 participants). We found a substantial deficit in median EQ-5D-5L utility index from before COVID-19 (retrospective assessment; 0·88 [IQR 0·74–1·00]), at 5 months (0·74 [0·64–0·88]) to 1 year (0·75 [0·62–0·88]), with minimal improvements across all outcome measures at 1 year after discharge in the whole cohort and within each of the four clusters. Interpretation: The sequelae of a hospital admission with COVID-19 were substantial 1 year after discharge across a range of health domains, with the minority in our cohort feeling fully recovered. Patient-perceived health-related quality of life was reduced at 1 year compared with before hospital admission. Systematic inflammation and obesity are potential treatable traits that warrant further investigation in clinical trials. Funding: UK Research and Innovation and National Institute for Health Research. | en_US |
dc.description.sponsorship | UK Research and Innovation and National Institute for Health Research | en_US |
dc.format.extent | 761 - 775 | - |
dc.publisher | Elsevier | en_US |
dc.rights | Copyright © 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.title | Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.1016/S2213-2600(22)00127-8 | - |
dc.relation.isPartOf | The Lancet Respiratory Medicine | - |
pubs.issue | 8 | - |
pubs.publication-status | Published | - |
pubs.volume | 10 | - |
dc.identifier.eissn | 2213-2619 | - |
dc.rights.holder | The Author(s) | - |
Appears in Collections: | Dept of Health Sciences Research Papers |
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FullText.pdf | Copyright © 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. | 2.09 MB | Adobe PDF | View/Open |
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