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DC Field | Value | Language |
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dc.contributor.author | Nolan, CM | - |
dc.contributor.author | Polgar, O | - |
dc.contributor.author | Schofield, SJ | - |
dc.contributor.author | Patel, S | - |
dc.contributor.author | Barker, RE | - |
dc.contributor.author | Walsh, JA | - |
dc.contributor.author | Ingram, KA | - |
dc.contributor.author | George, PM | - |
dc.contributor.author | Molyneaux, PL | - |
dc.contributor.author | Maher, TM | - |
dc.contributor.author | Man, WDC | - |
dc.date.accessioned | 2022-11-26T18:41:41Z | - |
dc.date.available | 2022-11-26T18:41:41Z | - |
dc.date.issued | 2021-10-23 | - |
dc.identifier.citation | Nolan, C.M. et al. (2022) 'Pulmonary Rehabilitation in Idiopathic Pulmonary Fibrosis and COPD: A Propensity-Matched Real-World Study', Chest, 161 (3), pp. 728 - 737. doi: 10.1016/j.chest.2021.10.021. | en_US |
dc.identifier.issn | 0012-3692 | - |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/25550 | - |
dc.description | Supplementary data available at: https://journal.chestnet.org/cms/10.1016/j.chest.2021.10.021/attachment/814ea172-99e4-4122-8fd1-15c25422db75/mmc1.pdf (21MB). | en_US |
dc.description.abstract | Cpyright © 2021 The Author(s). Background: The adherence to and clinical efficacy of pulmonary rehabilitation in idiopathic pulmonary fibrosis (IPF), particularly in comparison with COPD, remains uncertain. The objectives of this real-world study were to compare the responses of patients with IPF with a matched group of patients with COPD undergoing the same supervised, outpatient pulmonary rehabilitation program and to determine whether pulmonary rehabilitation is associated with survival in IPF. Research Question: Do people with IPF improve to the same extent with pulmonary rehabilitation as a matched group of individuals with COPD, and are noncompletion of or nonresponse to pulmonary rehabilitation, or both, associated with 1-year all-cause mortality in IPF? Study Design and Methods: Using propensity score matching, 163 patients with IPF were matched 1:1 with a control group of 163 patients with COPD referred for pulmonary rehabilitation. We compared between-group pulmonary rehabilitation completion rates and response. Survival status in the IPF cohort was recorded over 1 year after pulmonary rehabilitation discharge. Cox proportional hazards regression explored the association between pulmonary rehabilitation status and all-cause mortality. Results: Similar pulmonary rehabilitation completion rates (IPF, 69%; COPD, 63%; P = .24) and improvements in exercise response were observed in both groups with no significant mean between-group differences in incremental shuttle walk test (ISWT) change (mean, 2 m [95% CI, –18 to 22 m]). Pulmonary rehabilitation noncompletion (hazard ratio [HR], 5.62 [95% CI, 2.24-14.08]) and nonresponse (HR, 3.91 [95% CI, 1.54-9.93]) were associated independently with increased 1-year all-cause mortality in IPF. Interpretation: This real-word study demonstrated that patients with IPF have similar completion rates and magnitude of response to pulmonary rehabilitation compared with a matched group of patients with COPD. In IPF, noncompletion of and nonresponse to pulmonary rehabilitation were associated with increased all-cause mortality. These data reinforce the benefits of pulmonary rehabilitation in patients with IPF. | en_US |
dc.description.sponsorship | National Institute for Health Research Doctoral Research Fellowship [No. 2014-07-089 ] and a Medical Research Council New Investigator Research Grant [No. 98576 ]. T. M. M. is supported by a National Institute for Health Research Clinician Scientist Fellowship [Grant: CS-2013-13-017 ] and is a British Lung Foundation Chair in Respiratory Research [Grant: C17-3 ]. W. D.-C. M. is supported by the National Institute for Health Research and the British Lung Foundation . | en_US |
dc.format.extent | 728 - 737 | - |
dc.format.medium | Print-Electronic | - |
dc.language.iso | en | en_US |
dc.publisher | Elsevier Inc under license from the American College of Chest Physicians. | en_US |
dc.rights | Copyright © 2021 The Author(s). Published by Elsevier Inc under license from the American College of Chest Physicians. User License: Creative Commons Attribution – NonCommercial – NoDerivs (CC BY-NC-ND 4.0). | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.subject | COPD | en_US |
dc.subject | idiopathic pulmonary fibrosis | en_US |
dc.subject | prognosis | en_US |
dc.subject | pulmonary rehabilitation | en_US |
dc.title | Pulmonary Rehabilitation in Idiopathic Pulmonary Fibrosis and COPD: A Propensity-Matched Real-World Study | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.1016/j.chest.2021.10.021 | - |
dc.relation.isPartOf | Chest | - |
pubs.issue | 3 | - |
pubs.publication-status | Published | - |
pubs.volume | 161 | - |
dc.identifier.eissn | 1931-3543 | - |
dc.rights.holder | The Author(s) | - |
Appears in Collections: | Dept of Health Sciences Research Papers |
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FullText.pdf | Copyright © 2021 The Author(s). Published by Elsevier Inc under license from the American College of Chest Physicians. User License: Creative Commons Attribution – NonCommercial – NoDerivs (CC BY-NC-ND 4.0). | 517.17 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License