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DC Field | Value | Language |
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dc.contributor.author | Manca, R | - |
dc.contributor.author | Jones, SA | - |
dc.contributor.author | Venneri, A | - |
dc.date.accessioned | 2022-12-19T13:04:00Z | - |
dc.date.available | 2022-12-19T13:04:00Z | - |
dc.date.issued | 2022-10-13 | - |
dc.identifier | ORCID iDs: Riccardo Manca https://orcid.org/0000-0003-1715-6442; Annalena Venneri https://orcid.org/0000-0002-9488-2301. | - |
dc.identifier.citation | Manca, R., Jones, S.A. and Venneri, A. (2022) 'Macrostructural and Microstructural White Matter Alterations Are Associated with Apathy across the Clinical Alzheimer’s Disease Spectrum' in Brain Sciences, 12 (10). pp. 1 - 17. doi: 10.3390/brainsci12101383. | en_US |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/25657 | - |
dc.description | Data Availability Statement: All ADNI data are made publicly available upon request. | - |
dc.description | Supplementary Materials: The following supporting information can be downloaded at: https://www.mdpi.com/article/10.3390/brainsci12101383/s1, Figure S1: Significant regional GM volume differences (FWE-corrected at cluster level): A. ANCOVA; B. NA-PT < CU group; C. AP-PT < CU group; Table S1: Differences in the prevalence of individual neuropsychiatric symptoms (other than apathy) between patient groups (Chi-square test). All values are frequencies (proportions); Table S2: Differences in the prevalence of health issues in the medical history of participant groups (Chi-square test). All values are frequencies (proportions); Table S3: Differences in the prevalence of mental health problems in the medical history of participant groups (Chi-square test). All values are frequencies (proportions); Table S4: Differences in the prevalence of medications with a potential impact on apathy across participant groups (Chi-square test). All values are frequencies (proportions); Abbreviation list. | - |
dc.description.abstract | Copyright: © 2022 by the authors. Apathy is the commonest neuropsychiatric symptom in Alzheimer’s disease (AD). Previous findings suggest that apathy is caused by a communication breakdown between functional neural networks involved in motivational–affective processing. This study investigated the relationship between white matter (WM) damage and apathy in AD. Sixty-one patients with apathy (AP-PT) and 61 without apathy (NA-PT) were identified from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database and matched for cognitive status, age and education. Sixty-one cognitively unimpaired (CU) participants were also included as controls. Data on cognitive performance, cerebrospinal fluid biomarkers, brain/WM hyperintensity volumes and diffusion tensor imaging indices were compared across groups. No neurocognitive differences were found between patient groups, but the AP-PT group had more severe neuropsychiatric symptoms. Compared with CU participants, only apathetic patients had deficits on the Clock Drawing Test. AP-PT had increased WM damage, both macrostructurally, i.e., larger WM hyperintensity volume, and microstructurally, i.e., increased radial/axial diffusivity and reduced fractional anisotropy in the fornix, cingulum, anterior thalamic radiations and superior longitudinal and uncinate fasciculi. AP-PT showed signs of extensive WM damage, especially in associative tracts in the frontal lobes, fornix and cingulum. Disruption in structural connectivity might affect crucial functional inter-network communication, resulting in motivational deficits and worse cognitive decline. | en_US |
dc.format.extent | 1 - 17 | - |
dc.format.medium | Electronic | - |
dc.publisher | MDPI | en_US |
dc.rights | Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | Alzheimer’s disease | en_US |
dc.subject | apathy | en_US |
dc.subject | white matter | en_US |
dc.title | Macrostructural and Microstructural White Matter Alterations Are Associated with Apathy across the Clinical Alzheimer’s Disease Spectrum | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.3390/brainsci12101383 | - |
dc.relation.isPartOf | Brain Sciences | - |
pubs.issue | 10 | - |
pubs.publication-status | Published | - |
pubs.volume | 12 | - |
dc.identifier.eissn | 2076-3425 | - |
dc.rights.holder | The authors | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
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FullText.pdf | Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | 1.28 MB | Adobe PDF | View/Open |
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