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DC Field | Value | Language |
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dc.contributor.author | Shapiro, NL | - |
dc.contributor.author | Todd, EG | - |
dc.contributor.author | Billot, B | - |
dc.contributor.author | Cash, DM | - |
dc.contributor.author | Iglesias, JE | - |
dc.contributor.author | Warren, JD | - |
dc.contributor.author | Rohrer, JD | - |
dc.contributor.author | Bocchetta, M | - |
dc.date.accessioned | 2023-01-01T13:32:11Z | - |
dc.date.available | 2022-06-14 | - |
dc.date.available | 2023-01-01T13:32:11Z | - |
dc.date.issued | 2022-06-14 | - |
dc.identifier | ORCID iD: Martina Bocchetta https://orcid.org/0000-0003-1814-5024 | - |
dc.identifier | 103084 | - |
dc.identifier.citation | Shapiro, N.L. et al. (2022) 'In vivo hypothalamic regional volumetry across the frontotemporal dementia spectrum', NeuroImage: Clinical, 35, 103084, pp. 1 - 14. doi: 10.1016/j.nicl.2022.103084. | en_US |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/25684 | - |
dc.description | Appendix A. Supplementary data: The following are the Supplementary data to this article: Supplementary data 1. Available at: https://ars.els-cdn.com/content/image/1-s2.0-S2213158222001498-mmc1.docx (Word document (15MB)). | en_US |
dc.description.abstract | Copyright © 2022 The Author(s). Background: Frontotemporal dementia (FTD) is a spectrum of diseases characterised by language, behavioural and motor symptoms. Among the different subcortical regions implicated in the FTD symptomatology, the hypothalamus regulates various bodily functions, including eating behaviours which are commonly present across the FTD spectrum. The pattern of specific hypothalamic involvement across the clinical, pathological, and genetic forms of FTD has yet to be fully investigated, and its possible associations with abnormal eating behaviours have yet to be fully explored. Methods: Using an automated segmentation tool for volumetric T1-weighted MR images, we measured hypothalamic regional volumes in a cohort of 439 patients with FTD (197 behavioural variant FTD [bvFTD]; 7 FTD with associated motor neurone disease [FTD-MND]; 99 semantic variant primary progressive aphasia [svPPA]; 117 non-fluent variant PPA [nfvPPA]; 19 PPA not otherwise specified [PPA-NOS]) and 118 age-matched controls. We compared volumes across the clinical, genetic (29 MAPT, 32 C9orf72, 23 GRN), and pathological diagnoses (61 tauopathy, 40 TDP-43opathy, 4 FUSopathy). We correlated the volumes with presence of abnormal eating behaviours assessed with the revised version of the Cambridge Behavioural Inventory (CBI-R). Results: On average, FTD patients showed 14% smaller hypothalamic volumes than controls. The groups with the smallest hypothalamic regions were FTD-MND (20%), MAPT (25%) and FUS (33%), with differences mainly localised in the anterior and posterior regions. The inferior tuberal region was only significantly smaller in tauopathies (MAPT and Pick’s disease) and in TDP-43 type C compared to controls and was the only regions that did not correlate with eating symptoms. PPA-NOS and nfvPPA were the groups with the least frequent eating behaviours and the least hypothalamic involvement. Conclusions: Abnormal hypothalamic volumes are present in all the FTD forms, but different hypothalamic regions might play a different role in the development of abnormal eating behavioural and metabolic symptoms. These findings might therefore help in the identification of different underlying pathological mechanisms, suggesting the potential use of hypothalamic imaging biomarkers and the research of potential therapeutic targets within the hypothalamic neuropeptides. | en_US |
dc.description.sponsorship | The Dementia Research Centre is supported by Alzheimer's Research UK, Alzheimer's Society, Brain Research UK, and The Wolfson Foundation. This work was supported by the NIHR UCL/H Biomedical Research Centre, the Leonard Wolfson Experimental Neurology Centre (LWENC) Clinical Research Facility, and the UK Dementia Research Institute, which receives its funding from UK DRI Ltd, funded by the UK Medical Research Council, Alzheimer's Society and Alzheimer's Research UK. JDR is supported by the Miriam Marks Brain Research UK Senior Fellowship and has received funding from an MRC Clinician Scientist Fellowship (MR/M008525/1) and the NIHR Rare Disease Translational Research Collaboration (BRC149/NS/MH). This work was also supported by the MRC UK GENFI grant (MR/M023664/1), the Bluefield Project and the JPND GENFI-PROX grant (2019-02248). MB is supported by a Fellowship award from the Alzheimer’s Society, UK (AS-JF-19a-004-517). MB’s work was also supported by the UK Dementia Research Institute which receives its funding from DRI Ltd, funded by the UK Medical Research Council, Alzheimer’s Society and Alzheimer’s Research UK. MB acknowledges the support of NVIDIA Corporation with the donation of the Titan V GPU used for part of the analyses in this research. JEI is supported by the European Research Council (Starting Grant 677697, project BUNGEE-TOOLS), Alzheimer’s Research UK (ARUK-IRG2019A003) and the NIH (1RF1MH123195-01 and 1R01AG070988). JDW receives grant support from the Alzheimer's Society, Alzheimer's Research UK, the NIHR UCL/UCLH Biomedical Research Centre and a Frontotemporal Dementia Research Studentship in Memory of David Blechner (funded through The National Brain Appeal). | en_US |
dc.format.extent | 1 - 14 | - |
dc.format.medium | Electronic | - |
dc.language | English | - |
dc.language.iso | en_US | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | Copyright © 2022 The Author(s). Published by Elsevier Inc. under a Creative Commons license (https://creativecommons.org/licenses/by/4.0/). | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | frontotemporal dementia | en_US |
dc.subject | hypothalamus | en_US |
dc.subject | volumetry | en_US |
dc.subject | magnetic resonance imaging | en_US |
dc.title | In vivo hypothalamic regional volumetry across the frontotemporal dementia spectrum | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.1016/j.nicl.2022.103084 | - |
dc.relation.isPartOf | NeuroImage: Clinical | - |
pubs.publication-status | Published | - |
pubs.volume | 35 | - |
dc.identifier.eissn | 2213-1582 | - |
dc.rights.holder | The Author(s) | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
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FullText.pdf | Copyright © 2022 The Author(s). Published by Elsevier Inc. under a Creative Commons license (https://creativecommons.org/licenses/by/4.0/). | 3.39 MB | Adobe PDF | View/Open |
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