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http://bura.brunel.ac.uk/handle/2438/25718Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Russell, LL | - |
| dc.contributor.author | Greaves, CV | - |
| dc.contributor.author | Convery, RS | - |
| dc.contributor.author | Bocchetta, M | - |
| dc.contributor.author | Warren, JD | - |
| dc.contributor.author | Kaski, D | - |
| dc.contributor.author | Rohrer, JD | - |
| dc.date.accessioned | 2023-01-04T18:42:28Z | - |
| dc.date.available | 2023-01-04T18:42:28Z | - |
| dc.date.issued | 2021-12-31 | - |
| dc.identifier | ORCID iD: Martina Bocchetta https://orcid.org/0000-0003-1814-5024 | - |
| dc.identifier | e12218 | - |
| dc.identifier.citation | Russell, L.L. et al. (2021) 'Eye movements in frontotemporal dementia: Abnormalities of fixation, saccades and anti-saccades', Alzheimer's and Dementia: Translational Research and Clinical Interventions, 7 (1), e12218, pp. 1 - 14. doi: 10.1002/trc2.12218 | en_US |
| dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/25718 | - |
| dc.description.abstract | Copyright © 2021 The Authors. Introduction: Oculomotor function has not been systematically studied in frontotemporal dementia (FTD) and yet may offer a simple target to monitor disease activity. Methods: We assessed fixation stability, smooth pursuit, pro-saccades, and anti-saccades using the Eyelink 1000-plus eye-tracker in 19 individuals with behavioral variant FTD (bvFTD) and 22 controls. Neuroanatomical correlates were assessed using a region of interest magnetic resonance imaging (MRI) analysis. Results: Measures of fixation stability were impaired in the bvFTD group compared with controls. However, performance did not differ from controls in the pro-saccade tasks except in the vertical overlap condition. The bvFTD group performed worse in the anti-saccade task, which correlated strongly with executive function. Neural correlates included the orbitofrontal and ventromedial prefrontal cortices and striatum for fixation stability, and the dorsolateral prefrontal and parietal cortices and striatum for anti-saccades. Discussion: Overall, oculomotor function is abnormal in bvFTD, with performance likely related to impairment of inhibitory control and executive dysfunction. | en_US |
| dc.description.sponsorship | The Dementia Research Centre is supported by Alzheimer's Research UK, Alzheimer's Society, Brain Research UK, and The Wolfson Foundation. This work was supported by the NIHR UCL/H Biomedical Research Centre, the Leonard Wolfson Experimental Neurology Centre (LWENC) Clinical Research Facility, and the UK Dementia Research Institute, which receives its funding from UK DRI Ltd, funded by the UK Medical Research Council, Alzheimer's Society, and Alzheimer's Research UK. JDR is supported by an MRC Clinician Scientist Fellowship (MR/M008525/1) and has received funding from the NIHR Rare Disease Translational Research Collaboration (BRC149/NS/MH). This work was also supported by the MRC UK GENFI grant (MR/M023664/1), the Bluefield Project, and the JPND GENFI-PROX grant (2019-02248). MB is supported by a Fellowship award from the Alzheimer's Society, UK (AS-JF-19a-004-517). MB's work is also supported by the UK Dementia Research Institute, which receives its funding from DRI Ltd, funded by the UK Medical Research Council, Alzheimer's Society, and Alzheimer's Research UK. RC/CG are supported by a Frontotemporal Dementia Research Studentships in Memory of David Blechner funded through The National Brain Appeal (RCN 290173). JDW is supported by the Alzheimer's Society, Alzheimer's Research UK, and the UCLH/UCL NIHR Biomedical Research Centre. The GIF template database includes volumetric MRI scans from the University College London Genetic FTD Initiative (GENFI) study (www.genfi.org.uk), which is funded by the Medical Research Council UK GENFI grant (MR/M023664/1). | en_US |
| dc.format.extent | 1 - 14 | - |
| dc.format.medium | Electronic | - |
| dc.language | English | - |
| dc.language.iso | en_US | en_US |
| dc.publisher | Wiley Periodicals, LLC on behalf of Alzheimer's Association | en_US |
| dc.rights | Copyright © 2021 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. | - |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
| dc.title | Eye movements in frontotemporal dementia: Abnormalities of fixation, saccades and anti-saccades | en_US |
| dc.type | Article | en_US |
| dc.identifier.doi | https://doi.org/10.1002/trc2.12218 | - |
| dc.relation.isPartOf | Alzheimer's and Dementia: Translational Research and Clinical Interventions | - |
| pubs.issue | 1 | - |
| pubs.publication-status | Published | - |
| pubs.volume | 7 | - |
| dc.identifier.eissn | 2352-8737 | - |
| dc.rights.holder | The Authors | - |
| Appears in Collections: | Dept of Life Sciences Research Papers | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| FullText.pdf | Copyright © 2021 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. | 1.96 MB | Adobe PDF | View/Open |
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