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DC Field | Value | Language |
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dc.contributor.author | Clerbaux, L-A | - |
dc.contributor.author | Amigó, N | - |
dc.contributor.author | Amorim, MJ | - |
dc.contributor.author | Bal-Price, A | - |
dc.contributor.author | Batista Leite, S | - |
dc.contributor.author | Beronius, A | - |
dc.contributor.author | Bezemer, GFG | - |
dc.contributor.author | Bostroem, A-C | - |
dc.contributor.author | Carusi, A | - |
dc.contributor.author | Coecke, S | - |
dc.contributor.author | Concha, R | - |
dc.contributor.author | Daskalopoulos, EP | - |
dc.contributor.author | Debernardi, F | - |
dc.contributor.author | Edrosa, E | - |
dc.contributor.author | Edwards, SW | - |
dc.contributor.author | Filipovska, J | - |
dc.contributor.author | Garcia-Reyero, N | - |
dc.contributor.author | Gavins, FNE | - |
dc.contributor.author | Halappanavar, S | - |
dc.contributor.author | Hargreaves, AJ | - |
dc.contributor.author | Hogberg, HT | - |
dc.contributor.author | Huynh, MT | - |
dc.contributor.author | Jacobson, D | - |
dc.contributor.author | Josephs-Spaulding, J | - |
dc.contributor.author | Kim, YJ | - |
dc.contributor.author | Kong, HJ | - |
dc.contributor.author | Krebs, CE | - |
dc.contributor.author | Lam, A | - |
dc.contributor.author | Landesmann, B | - |
dc.contributor.author | Layton, AR | - |
dc.contributor.author | Lee, YO | - |
dc.contributor.author | Macmillan, DS | - |
dc.contributor.author | Mantovani, A | - |
dc.contributor.author | Margiotta-Casaluci, L | - |
dc.contributor.author | Martens, M | - |
dc.contributor.author | Masereeuw, R | - |
dc.contributor.author | Mayasich, SA | - |
dc.contributor.author | Mei, LM | - |
dc.contributor.author | Mortensen, H | - |
dc.contributor.author | Munoz Pineiro, A | - |
dc.contributor.author | Nymark, P | - |
dc.contributor.author | Ohayon, E | - |
dc.contributor.author | Ojasi, JM | - |
dc.contributor.author | Paini, A | - |
dc.contributor.author | Parissis, N | - |
dc.contributor.author | Parvatam, S | - |
dc.contributor.author | Pistollato, F | - |
dc.contributor.author | Sachana, M | - |
dc.contributor.author | Sørli, JB | - |
dc.contributor.author | Sullivan, KM | - |
dc.contributor.author | Sund, J | - |
dc.contributor.author | Tanabe, S | - |
dc.contributor.author | Tsaioun, K | - |
dc.contributor.author | Vinken, M | - |
dc.contributor.author | Viviani, L | - |
dc.contributor.author | Waspe, J | - |
dc.contributor.author | Willett, C | - |
dc.contributor.author | Wittwehr, C | - |
dc.date.accessioned | 2023-01-10T18:14:07Z | - |
dc.date.available | 2022-04-11 | - |
dc.date.available | 2023-01-10T18:14:07Z | - |
dc.date.issued | 2022-04-11 | - |
dc.identifier | ORCID iDs: Felicity N.E. Gavins https://orcid.org/0000-0001-7008-5423; Luigi Margiotta-Casaluci https://orcid.org/0000-0001-6938-0396. | - |
dc.identifier.citation | Clerbaux, L.-A. et al. (2022) 'COVID-19 through Adverse Outcome Pathways: Building networks to better understand the disease - 3rd CIAO AOP Design Workshop', ALTEX - Alternatives to Animal Experimentation, 2022, 39 (2), pp. 322 - 335. doi: 10.14573/altex.2112161. | en_US |
dc.identifier.issn | 1868-596X | - |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/25755 | - |
dc.description | ALTEX - Alternatives to Animal Experimentation | en_US |
dc.description.abstract | Copyright © 2022 the author(s). On April 28-29, 2021, 50 scientists from different fields of expertise met for the 3rd online CIAO workshop. The CIAO project “Modelling the Pathogenesis of COVID-19 using the Adverse Outcome Pathway (AOP) framework” aims at building a holistic assembly of the available scientific knowledge on COVID-19 using the AOP framework. An individual AOP depicts the disease progression from the initial contact with the SARS-CoV-2 virus through biological key events (KE) toward an adverse outcome such as respiratory distress, anosmia or multiorgan failure. Assembling the individual AOPs into a network highlights shared KEs as central biological nodes involved in multiple outcomes observed in COVID-19 patients. During the workshop, the KEs and AOPs established so far by the CIAO members were presented and positioned on a timeline of the disease course. Modulating factors influencing the progression and severity of the disease were also addressed as well as factors beyond purely biological phenomena. CIAO relies on an interdisciplinary crowdsourcing effort, therefore, approaches to expand the CIAO network by widening the crowd and reaching stakeholders were also discussed. To conclude the workshop, it was decided that the AOPs/KEs will be further consolidated, integrating virus variants and long COVID when relevant, while an outreach campaign will be launched to broaden the CIAO scientific crowd. | en_US |
dc.description.sponsorship | The CIAO project is steered by the Joint Research Centre of the European Commission (EC-JRC), the Humane Society International (HSI), and the Physicians Committee for Responsible Medicine (PCRM). For Jorid Birkelund Sørli, the research is supported by FIKA, Focused Research Effort on Chemicals in the Working Environment from the Danish Government. For Daniel Jacobson, this work was supported by the Laboratory Directed Research and Development Program of Oak Ridge National Laboratory, managed by UT-Battelle, LLC for the US Department of Energy (LOIS:10074) and the National Institutes of Health 3RF1AG053303-01S2. | en_US |
dc.format.extent | 322 - 335 | - |
dc.format.medium | Print-Electronic | - |
dc.language | English | - |
dc.language.iso | en_US | en_US |
dc.publisher | Heidelberg Spektrum, Akad. Verl. | en_US |
dc.rights | Copyright © 2022 the author(s). This work is licensed under a Creative Commons Attribution 4.0 International License. Articles are distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the original work is appropriately cited (CC-BY). Copyright on any article in ALTEX is retained by the author(s). | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | COVID-19 | en_US |
dc.subject | interdisciplinarity | en_US |
dc.subject | adverse outcome pathway | en_US |
dc.title | COVID-19 through Adverse Outcome Pathways: Building networks to better understand the disease - 3rd CIAO AOP Design Workshop | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.14573/altex.2112161 | - |
dc.relation.isPartOf | ALTEX - Alternatives to Animal Experimentation | - |
pubs.issue | 2 | - |
pubs.publication-status | Published | - |
pubs.volume | 39 | - |
dc.identifier.eissn | 1868-8551 | - |
dc.rights.holder | The author(s) | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
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