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DC Field | Value | Language |
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dc.contributor.author | Diana, M | - |
dc.contributor.author | Farré, MJ | - |
dc.contributor.author | Sanchís, J | - |
dc.contributor.author | Kanda, R | - |
dc.contributor.author | Felipe-Sotelo, M | - |
dc.contributor.author | Bond, T | - |
dc.date.accessioned | 2023-01-24T13:10:07Z | - |
dc.date.available | 2023-01-24T13:10:07Z | - |
dc.date.issued | 2022-12-22 | - |
dc.identifier | ORCiD: Maria José Farré https://orcid.org/0000-0002-8971-3722 | - |
dc.identifier | ORCiD: Josep Sanchís https://orcid.org/0000-0002-7307-4372 | - |
dc.identifier | ORCiD: Rakesh Kanda https://orcid.org/0000-0002-5427-3982 | - |
dc.identifier | ORCiD: Tom Bond https://orcid.org/0000-0002-5546-0210 | - |
dc.identifier.citation | Bond, T. et al. (2023) ‘The formation of furan-like disinfection byproducts from phenolic precursors' Environmental Science: Water Research & Technology. 9, pp..419 - 432. doi: 10.1039/d2ew00803c. | en_US |
dc.identifier.issn | 2053-1400 | - |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/25866 | - |
dc.description.abstract | In this study, it was hypothesised that UV-absorbing disinfection byproducts (DBPs) may include compounds, such as halofuranones, prioritized as candidates for explaining the increased risk of bladder cancer associated with the consumption of chlorinated water highlighted by epidemiological studies. Hence, UV spectroscopy was used as a screening method to identify conditions forming stable UV-absorbing DBPs from 10 phenolic precursors at various pH levels, chlorine and bromide doses. Subsequently, high performance liquid chromatography coupled to high resolution mass spectrometry (Orbitrap™) was used to elucidate the chemical formulas of 30 stable DBPs, 12 of which were tentatively identified as furan-like structures, including trichlorofuran-2-carboxylic acid, dichlorofuran-2-carboxylic acid, 3,4-dichlorofuran-2,5-dicarbaldehyde, 4-chloro-5-(dichloromethyl)furan-2,3-dione, 5-formyl-2-furancarboxylic acid, chloro-5-methyl-2-furancarboxylic acid, 2-acetylchlorofuran-5-one and bromo-2-furancarboxylic acid. Eleven of the furan-like structures are previously unknown as DBPs. A novel pathway was proposed to explain their formation, involving the opening of the oxidised phenolic ring followed by the formation of a 5-membered ring by intramolecular nucleophilic addition. Of the 12 furan-like DBPs identified, eight and three were respectively predicted to be mutagens and bladder carcinogens, using a quantitative structure–activity relationship theoretical model. The findings indicate the formation of furan-like DBPs from natural organic matter surrogates is more widespread than previously appreciated. Moreover, this class of DBPs may be toxicologically significant for the urinary bladder. | en_US |
dc.description.sponsorship | The Department of Civil and Environmental Engineering at the University of Surrey is gratefully acknowledged for funding this project. ICRA researchers thank funding from the CERCA program. MJF acknowledges her Ramón y Cajal fellowship (RyC-2015-17108), from the AEI-MICIU. | en_US |
dc.format.extent | 419 - 432 | - |
dc.format.medium | Print-Electronic | - |
dc.language | English | - |
dc.publisher | Royal Society of Chemistry (RSC) | en_US |
dc.rights | Copyright © 2022 The Author(s). Open Access article. Published by Royal Society of Chemistry on 22 December 2022. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence (https://creativecommons.org/licenses/by-nc/3.0/). | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/3.0/ | - |
dc.title | The formation of furan-like disinfection byproducts from phenolic precursors | en_US |
dc.type | Article | en_US |
dc.date.dateAccepted | 2022-12-20 | - |
dc.identifier.doi | https://doi.org/10.1039/d2ew00803c | - |
dc.relation.isPartOf | Environmental Science: Water Research & Technology | - |
pubs.publication-status | Published | - |
pubs.volume | 9 | - |
dc.identifier.eissn | 2053-1419 | - |
dc.rights.license | https://creativecommons.org/licenses/by-nc/3.0/legalcode.en | - |
dc.rights.holder | The Author(s) | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
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