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http://bura.brunel.ac.uk/handle/2438/25875Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Manca, R | - |
| dc.contributor.author | Venneri, A | - |
| dc.date.accessioned | 2023-01-26T12:34:03Z | - |
| dc.date.available | 2021-02-22 | - |
| dc.date.available | 2023-01-26T12:34:03Z | - |
| dc.date.issued | 2021-02-22 | - |
| dc.identifier | ORCID iDs: Riccardo Manca https://orcid.org/0000-0003-1715-6442; Annalena Venneri https://orcid.org/0000-0002-9488-2301. | - |
| dc.identifier.citation | Manca, R. and Venneri, A. (2020) 'A Comparison of Neurocognitive Decline in Older Adults in Same-Sex and Opposite-Sex Relationships', Current Alzheimer Research, 17 (12), pp. 1102 - 1114. doi: 10.2174/1567205018666210114111556. | en_US |
| dc.identifier.issn | 1567-2050 | - |
| dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/25875 | - |
| dc.description.abstract | Background: Individuals from sexual minorities experience health inequalities that have detrimental impacts on their health, especially in the elderly, by exacerbating care needs and symptoms of chronic conditions such as Alzheimer’s disease (AD). Neurocognitive decline due to AD in the sexual minority population remains under-investigated. However, being in a relationship may mitigate the risk of experiencing cognitive impairment. Objective: The aim of this study was to investigate whether cognitive decline and brain atrophy may differ in people from sexual minorities. Methods: Clinical data for this study were selected from the National Alzheimer’s Coordinating Center’s Uniform Data Set and structural MRI data collected across 14 Alzheimer’s Disease Centers. Eighty participants including 20 patients with AD and 20 healthy controls (HC) in same-sex relationships were identified and matched to groups of participants (20 AD and 20 HC) in opposite-sex relationships. The effects of diagnosis and relationship were investigated on all measures. Results: No diagnosis-by-relationship interactions were found on any variable. However, post hoc analyses revealed that the opposite-sex group had grey matter atrophy mainly in medio-temporal areas. In the same-sex group, atrophy also extended to pre-frontal and cingulate areas. The severity of neuropsychiatric symptoms correlated with volume of pre-frontal and insular/temporal areas only in the same-sex group. Conclusion: Neurocognitive decline due to AD may express similarly across individuals, independently of relationship type, thus suggesting a protective role of relational status. However, the same-sex group appeared to be more likely to experience at least one neuropsychiatric symptom and to have atrophy extending to fronto-limbic areas. | en_US |
| dc.description.sponsorship | The NACC database is funded by NIA/NIH Grant U 01 AG016976. NACC data are contributed by the NIAfunded ADCs: P30 AG019610 (PI Eric Reiman, MD), P30 AG013846 (PI Neil Kowall, MD), P30 AG062428 01 (PI James Leverenz, MD) P50 AG008702 (PI Scott Small, MD), P50 AG025688 (PI Allan Levey, MD, PhD), P50 AG047266 (PI Todd Golde, MD, PhD), P30 AG010133 (PI Andrew Saykin, PsyD), P50 AG005146 (PI Marilyn Albert, PhD), P30 AG06242101 (PI Bradley Hyman, MD, PhD), P30 AG062422 Petersen, MD, PhD), P50 AG005138 (PI Mary Sano, PhD), P30 AG008051 (PI Thom01 (PI Ronald as Wisniewski, MD), P30 AG013854 (PI Robert Vassar, PhD), P30 AG008017 (PI Jeffrey Kaye, MD), P30 AG010161 (PI David Bennett, MD), P50 AG047366 (PI Victor Henderson, MD, MS), P30 AG010129 (PI Charles DeCarli, MD), P50 AG016573 (PI Frank LaFerla, PhD), P30 AG06242901(PI James Brewer, MD, PhD), P50 AG023501 (PI Bruce Miller, MD), P30 AG035982 (PI Russell Swerdlow, MD), P30 AG028383 (PI Linda Van Eldik, PhD), P30 AG053760 (PI Henry Paulson, MD, PhD), P30 AG010124 (PI John Trojanowski, MD, PhD), P50 AG005133 ( PI Oscar Lopez, MD), P50 AG005142 (PI Helena Chui, MD), P30 AG012300 (PI Roger Rosenberg, MD), P30 AG049638 (PI Suzanne Craft, PhD), P50 AG005136 (PI Thomas Grabowski, MD), P30 AG06271501 (PI Sanjay Asthana, MD, FRCP), P50 AG005681 (PI John Morris, MD), P Stephen Strittmatter, MD, PhD). 50 AG047270 (PI This is a summary of independent research carried out at the NIHR Sheffield Biomedical Research Centre (Translational Neuroscience). The views expressed are those of the authors and not necessarily those of NHS, the NIHR or the Department of Health. RM is funded by a grant from Neurocare to AV. the | en_US |
| dc.format.extent | 1102 - 1114 | - |
| dc.format.medium | Print-Electronic | - |
| dc.language.iso | en_US | en_US |
| dc.publisher | Bentham Science Publishers | en_US |
| dc.rights | Copyright © 2021 Bentham Science Publishers. This is the accepted manuscript of the peer-reviewed article, archived under under the terms of the Creative Commons License CC BY-NC-ND 4.0 - Attribution-NonCommercial-NoDerivatives 4.0 International. The published manuscript is available at EurekaSelect via https://www.eurekaselect.com/openurl/content.php?genre=article&doi=10.2174/1567205018666210114111556 (see: https://www.benthamscience.com/self-archiving-policies). | - |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
| dc.subject | Alzheimer’s disease | en_US |
| dc.subject | neurodegeneration | en_US |
| dc.subject | marital relationship | en_US |
| dc.subject | sexual minorities | en_US |
| dc.subject | neuropsychiatric symptoms | en_US |
| dc.subject | cognition | en_US |
| dc.title | A Comparison of Neurocognitive Decline in Older Adults in Same-Sex and Opposite-Sex Relationships | en_US |
| dc.type | Article | en_US |
| dc.identifier.doi | https://doi.org/10.2174/1567205018666210114111556 | - |
| dc.relation.isPartOf | Current Alzheimer Research | - |
| pubs.issue | 12 | - |
| pubs.notes | Neurocognitive decline due to AD may express similarly across individuals, independently of relationship type, thus suggesting a protective role of relational status. However, the same-sex group appeared to be more likely to experience at least one neuropsychiatric symptom and to have atrophy extend … | - |
| pubs.publication-status | Published | - |
| pubs.volume | 17 | - |
| dc.identifier.eissn | 1875-5828 | - |
| dc.rights.holder | Bentham Science Publishers | - |
| Appears in Collections: | Dept of Life Sciences Research Papers | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| FullText.pdf | Copyright © 2021 Bentham Science Publishers. This is the accepted manuscript of the peer-reviewed article, archived under under the terms of the Creative Commons License CC BY-NC-ND 4.0 - Attribution-NonCommercial-NoDerivatives 4.0 International. The published manuscript is available at EurekaSelect via https://www.eurekaselect.com/openurl/content.php?genre=article&doi=10.2174/1567205018666210114111556 (see: https://www.benthamscience.com/self-archiving-policies). | 514.7 kB | Adobe PDF | View/Open |
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