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DC Field | Value | Language |
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dc.contributor.author | Tavares, AM | - |
dc.contributor.author | Viegas, S | - |
dc.contributor.author | Louro, H | - |
dc.contributor.author | Göen, T | - |
dc.contributor.author | Santonen, T | - |
dc.contributor.author | Luijten, M | - |
dc.contributor.author | Kortenkamp, A | - |
dc.contributor.author | Silva, MJ | - |
dc.date.accessioned | 2023-05-04T08:44:14Z | - |
dc.date.available | 2023-05-04T08:44:14Z | - |
dc.date.issued | 2022-07-25 | - |
dc.identifier | ORCID iDs: Susana Viegas https://orcid.org/0000-0003-1015-8760; Henriqueta Louro https://orcid.org/0000-0001-9744-7332; Thomas Göen https://orcid.org/0000-0002-8226-9227; Tiina Santonen https://orcid.org/0000-0002-8150-4985; Mirjam Luijten https://orcid.org/0000-0002-5277-1443; Andreas Kortenkamp https://orcid.org/0000-0001-9055-9729; Maria João Silva https://orcid.org/0000-0002-6060-0716. | - |
dc.identifier | 431 | - |
dc.identifier.citation | Tavares, A.M. et al. (2022) 'Occupational Exposure to Hexavalent Chromium, Nickel and PAHs: A Mixtures Risk Assessment Approach Based on Literature Exposure Data from European Countries', Toxics, 10 (8), 431, pp. 1 - 20. doi: 10.3390/toxics10080431. | en_US |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/26382 | - |
dc.description | Data Availability Statement: Not applicable. | en_US |
dc.description.abstract | Copyright © 2022 by the authors. Hexavalent chromium (Cr(VI)), nickel (Ni) and polycyclic aromatic hydrocarbons (PAHs) are genotoxic co-occurring lung carcinogens whose occupational health risk is still understudied. This study, conducted within the European Human Biomonitoring Initiative (HBM4EU), aimed at performing a mixtures risk assessment (MRA) based on published human biomonitoring (HBM) data from Cr(VI), Ni and/or PAHs occupational co-exposure in Europe. After data extraction, Risk Quotient (RQ) and Sum of Risk Quotients (SRQ) were calculated for binary and ternary mixtures to characterise the risk. Most selected articles measured urinary levels of Cr and Ni and a SRQ > 1 was obtained for co-exposure levels in welding activities, showing that there is concern regarding co-exposure to these substances. Similarly, co-exposure to mixtures of Cr(VI), Ni and PAHs in waste incineration settings resulted in SRQ > 1. In some studies, a low risk was estimated based on the single substances’ exposure level (RQ < 1), but the mixture was considered of concern (SRQ > 1), highlighting the relevance of considering exposure to the mixture rather than to its single components. Overall, this study points out the need of using a MRA based on HBM data as a more realistic approach to assess and manage the risk at the workplace, in order to protect workers’ health. | en_US |
dc.description.sponsorship | This research was funded by European Unions’ Horizon 2020 research and innovation Programme under grant agreement No 733032 HBM4EU and co-funded by UIDP/00009/2020; UIDB/00009/2020 (Centre for Toxicogenomics and Human Health—ToxOmics, FCT). | en_US |
dc.format.extent | 1 - 20 | - |
dc.format.medium | Electronic | - |
dc.language.iso | en_US | en_US |
dc.publisher | MDPI | en_US |
dc.rights | Copyright © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | human biomonitoring (HBM) | en_US |
dc.subject | European Human Biomonitoring Initiative (HBM4EU) | en_US |
dc.subject | co-exposure | en_US |
dc.subject | workplace; mixture risk assessment (MRA) | en_US |
dc.title | Occupational Exposure to Hexavalent Chromium, Nickel and PAHs: A Mixtures Risk Assessment Approach Based on Literature Exposure Data from European Countries | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.3390/toxics10080431 | - |
dc.relation.isPartOf | Toxics | - |
pubs.issue | 8 | - |
pubs.publication-status | Published | - |
pubs.volume | 10 | - |
dc.identifier.eissn | 2305-6304 | - |
dc.rights.holder | The authors | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
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