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DC Field | Value | Language |
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dc.contributor.author | Bipin, M | - |
dc.contributor.author | Premkumar, P | - |
dc.contributor.author | Das, MK | - |
dc.contributor.author | Lau, JY | - |
dc.contributor.author | Sumich, AL | - |
dc.contributor.author | Kumari, V | - |
dc.date.accessioned | 2023-05-18T12:47:13Z | - |
dc.date.available | 2023-05-18T12:47:13Z | - |
dc.date.issued | 2021-06-15 | - |
dc.identifier | ORCID iD: Veena Kumari https://orcid.org/0000-0002-9635-5505 | - |
dc.identifier | 111323 | - |
dc.identifier.citation | Bipin, M. et al . (2021) 'Pituitary volume in people with chronic schizophrenia: Clarifying the roles of serious violence and childhood maltreatment', Psychiatry Research - Neuroimaging, 314, 111323, pp. 1 - 7. doi: 10.1016/j.pscychresns.2021.111323. | en_US |
dc.identifier.issn | 0925-4927 | - |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/26471 | - |
dc.description.abstract | Aberrations in stress-linked hypothalamic-pituitary-adrenal axis function have been independently associated with schizophrenia, antisocial behaviour and childhood maltreatment. In this study, we examined pituitary volume (PV) in relation to childhood maltreatment (physical abuse, sexual abuse, neglect) in men (i) with schizophrenia and a history of serious violence (n = 13), (ii) with schizophrenia but without a history of serious violence (n = 15), (iii) with antisocial personality disorder (ASPD) and a history of serious violence (n = 13), and (iv) healthy participants without a history of violence (n = 15). All participants underwent whole-brain magnetic resonance imaging. Experiences of childhood maltreatment were rated based on interviews (for all), and case history and clinical/forensic records (for patients only). There was a trend for smaller PV, on average, in schizophrenia patients (regardless of a history of violence), compared to the healthy group and the ASPD group; other group differences in PV were non-significant. Sexual abuse ratings correlated negatively with PVs in ASPD participants, but no significant association between childhood maltreatment and PV was found in schizophrenia participants. Our findings are consistent with previous evidence of smaller-than-normal PV in chronic schizophrenia patients, and suggest that illness-related influences may mask the possible sexual abuse-smaller PV association, seen here in ASPD, in this population. | en_US |
dc.description.sponsorship | Zito Trust and the Community Fund, UK (RB218188); Medical Research Council, UK (MR/N006194/1). | en_US |
dc.format.medium | Print-Electronic | - |
dc.language.iso | en_US | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | Copyright © 2021 Elsevier B.V. All rights reserved. This is the accepted manuscript version of an article which has been published in final form at https://doi.org/10.1016/j.pscychresns.2021.111323, made available on this repository under a Creative Commons CC BY-NC-ND attribution licence (https://creativecommons.org/licenses/by-nc-nd/4.0/). | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.subject | sexual abuse | en_US |
dc.subject | physical abuse | en_US |
dc.subject | violence | en_US |
dc.subject | MRI | en_US |
dc.subject | stress | en_US |
dc.title | Pituitary volume in people with chronic schizophrenia: Clarifying the roles of serious violence and childhood maltreatment | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.1016/j.pscychresns.2021.111323 | - |
dc.relation.isPartOf | Psychiatry Research - Neuroimaging | - |
pubs.publication-status | Published | - |
pubs.volume | 314 | - |
dc.identifier.eissn | 1872-7506 | - |
dc.rights.holder | Elsevier B.V. | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
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FullText.pdf | Copyright © 2021 Elsevier B.V. All rights reserved. This is the accepted manuscript version of an article which has been published in final form at https://doi.org/10.1016/j.pscychresns.2021.111323, made available on this repository under a Creative Commons CC BY-NC-ND attribution licence (https://creativecommons.org/licenses/by-nc-nd/4.0/). | 486.61 kB | Adobe PDF | View/Open |
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