Please use this identifier to cite or link to this item:
http://bura.brunel.ac.uk/handle/2438/26852
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sprong, C | - |
dc.contributor.author | te Biesebeek, JD | - |
dc.contributor.author | Chatterjee, M | - |
dc.contributor.author | Wolterink, G | - |
dc.contributor.author | van den Brand, A | - |
dc.contributor.author | Blaznik, U | - |
dc.contributor.author | Christodoulou, D | - |
dc.contributor.author | Crépet, A | - |
dc.contributor.author | Hamborg Jensen, B | - |
dc.contributor.author | Sokolić, D | - |
dc.contributor.author | Rauscher-Gabernig, E | - |
dc.contributor.author | Ruprich, J | - |
dc.contributor.author | Kortenkamp, A | - |
dc.contributor.author | van Klaveren, J | - |
dc.date.accessioned | 2023-07-27T15:20:22Z | - |
dc.date.available | 2023-07-27T15:20:22Z | - |
dc.date.issued | 2023-05-05 | - |
dc.identifier | ORCID iDs: Gerrit Wolterink https://orcid.org/0000-0001-8825-984X; Mousumi Chatterjee https://orcid.org/0000-0002-6561-3006; Elke Rauscher-Gabernig https://orcid.org/0000-0002-6219-3632; Andreas Kortenkamp https://orcid.org/0000-0001-9055-9729.. | - |
dc.identifier | 114167 | - |
dc.identifier.citation | Sprong, C. et al. (2023) ‘A case study of neurodevelopmental risks from combined exposures to lead, methyl-mercury, inorganic arsenic, polychlorinated biphenyls, polybrominated diphenyl ethers and fluoride’ in International Journal of Hygiene and Environmental Health, 251, 114167, pp. 1 - 22. doi:.10.1016/j.ijheh.2023.114167. | en_US |
dc.identifier.issn | 1438-4639 | - |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/26852 | - |
dc.description | Supplementary data are available online at https://www.sciencedirect.com/science/article/pii/S1438463923000585?casa_token=naZFJvsrk3oAAAAA:NCz_PBUhbDGdiRpq5yzDyV8WHa3JIeGjc5f1LMf9ScHurJ_2vzVWPQ0yswkcjE_NHBrnPLhB9x0#appsec1 . | - |
dc.description.abstract | Copyright © 2023 The Authors. We performed a mixture risk assessment (MRA) case study of dietary exposure to the food contaminants lead, methylmercury, inorganic arsenic (iAs), fluoride, non-dioxin-like polychlorinated biphenyls (NDL-PCBs) and polybrominated diphenyl ethers (PBDEs), all substances associated with declines in cognitive abilities measured as IQ loss. Most of these chemicals are frequently measured in human biomonitoring studies. A component-based, personalised modified reference point index (mRPI) approach, in which we expressed the exposures and potencies of our chosen substances as lead equivalent values, was applied to perform a MRA for dietary exposures. We conducted the assessment for four different age groups (toddlers, children, adolescents, and women aged 18–45 years) in nine European countries. Populations in all countries considered exceeded combined tolerable levels at median exposure levels. NDL-PCBs in fish, other seafood and dairy, lead in grains and fruits, methylmercury in fish and other seafoods, and fluoride in water contributed most to the combined exposure. We identified uncertainties for the likelihood of co-exposure, assessment group membership, endpoint-specific reference values (ESRVs) based on epidemiological (lead, methylmercury, iAs, fluoride and NDL-PCBs) and animal data (PBDE), and exposure data. Those uncertainties lead to a complex pattern of under- and overestimations, which would require probabilistic modelling based on expert knowledge elicitation for integration of the identified uncertainties into an overall uncertainty estimate. In addition, the identified uncertainties could be used to refine future MRA for cognitive decline. | en_US |
dc.description.sponsorship | European Union’s Horizon 2020 research and innovation programme under grant agreement number 874583—the Advancing Tools for Human Early Lifecourse Exposome Research and Translation (ATHLETE) project. The author Mousumi Chatterjee is grateful for a Daphne Jackson Trust (UK) fellowship. The authors would like to thank EFSA providing the food consumption databases, data owners for giving permission to use the data, and Gerda van Donkersgoed and Matthijs Sam (RIVM) for organising the food consumption data and chemical concentration data. | en_US |
dc.format.medium | Print-Electronic | - |
dc.format.medium | 1 - 22 | - |
dc.publisher | Elsevier | en_US |
dc.rights | Copyright © 2023 The Authors. Published by Elsevier. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/). | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0 | - |
dc.subject | real-life mixture | en_US |
dc.subject | co-exposure | en_US |
dc.subject | dietary exposure | en_US |
dc.subject | developmental neurotoxicity | en_US |
dc.subject | contaminants | en_US |
dc.subject | mixture risk assessment | en_US |
dc.title | A case study of neurodevelopmental risks from combined exposures to lead, methyl-mercury, inorganic arsenic, polychlorinated biphenyls, polybrominated diphenyl ethers and fluoride | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.1016/j.ijheh.2023.114167 | - |
dc.relation.isPartOf | International Journal of Hygiene and Environmental Health | - |
pubs.publication-status | Published | - |
pubs.volume | 251 | - |
dc.identifier.eissn | 1618-131X | - |
dc.rights.holder | The Authors | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
FullText.pdf | Copyright © 2023 The Authors. Published by Elsevier. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/). | 3.31 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License