Please use this identifier to cite or link to this item: http://bura.brunel.ac.uk/handle/2438/27232
Full metadata record
DC FieldValueLanguage
dc.contributor.authorDi Tella, S-
dc.contributor.authorDe Marco, M-
dc.contributor.authorBaglio, F-
dc.contributor.authorSilveri, MC-
dc.contributor.authorVenneri, A-
dc.date.accessioned2023-09-22T06:51:55Z-
dc.date.available2023-09-22T06:51:55Z-
dc.date.issued2023-08-25-
dc.identifierORCiD: Matteo De Marco https://orcid.org/0000-0002-9240-8067-
dc.identifierORCiD: Annalena Venneri https://orcid.org/0000-0002-9488-2301-
dc.identifier1207988-
dc.identifier.citationDi Tella, S. et al. (2023) 'Resting-state functional connectivity is modulated by cognitive reserve in early Parkinson’s disease', Frontiers in Psychology, 14, 1207988, pp. 1 - 15. doi: 10.3389/fpsyg.2023.1207988.en_US
dc.identifier.urihttps://bura.brunel.ac.uk/handle/2438/27232-
dc.descriptionData availability statement: The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.en_US
dc.descriptionSupplementary material: The Supplementary material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fpsyg.2023.1207988/full#supplementary-material-
dc.description.abstractBackground: Fronto-striatal disconnection is thought to be at the basis of dysexecutive symptoms in patients with Parkinson’s disease (PD). Multiple reserve-related processes may offer resilience against functional decline. Among these, cognitive reserve (CR) refers to the adaptability of cognitive processes. Objective: To test the hypothesis that functional connectivity of pathways associated with executive dysfunction in PD is modulated by CR. Methods: Twenty-six PD patients and 24 controls underwent resting-state functional magnetic resonance imaging. Functional connectivity was explored with independent component analysis and seed-based approaches. The following networks were selected from the outcome of the independent component analysis: default-mode (DMN), left and right fronto-parietal (l/rFPN), salience (SalN), sensorimotor (SMN), and occipital visual (OVN). Seed regions were selected in the substantia nigra and in the dorsolateral and ventromedial prefrontal cortex for the assessment of seed-based functional connectivity maps. Educational and occupational attainments were used as CR proxies. Results: Compared with their counterparts with high CR, PD individuals with low CR had reduced posterior DMN functional connectivity in the anterior cingulate and basal ganglia, and bilaterally reduced connectivity in fronto-parietal regions within the networks defined by the dorsolateral and ventrolateral prefrontal seeds. Hyper-connectivity was detected within medial prefrontal regions when comparing low-CR PD with low-CR controls. Conclusion: CR may exert a modulatory effect on functional connectivity in basal ganglia and executive-attentional fronto-parietal networks. In PD patients with low CR, attentional control networks seem to be downregulated, whereas higher recruitment of medial frontal regions suggests compensation via an upregulation mechanism. This upregulation might contribute to maintaining efficient cognitive functioning when posterior cortical function is progressively reduced.en_US
dc.description.sponsorshipItalian Ministry of Health (Ricerca Corrente).en_US
dc.format.extent1 - 15-
dc.format.mediumElectronic-
dc.language.isoen_USen_US
dc.publisherFrontiers Mediaen_US
dc.rightsCopyright © 2023 Di Tella, De Marco, Baglio, Silveri and Venneri. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.-
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/-
dc.subjectfunctional MRIen_US
dc.subjectimagingen_US
dc.subjectParkinson’s diseaseen_US
dc.subjectresting-state networksen_US
dc.subjectcognitive reserveen_US
dc.subjectbrain reserveen_US
dc.titleResting-state functional connectivity is modulated by cognitive reserve in early Parkinson’s diseaseen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.3389/fpsyg.2023.1207988-
dc.relation.isPartOfFrontiers in Psychology-
pubs.publication-statusPublished online-
pubs.volume14-
dc.identifier.eissn1664-1078-
dc.rights.licensehttps://creativecommons.org/licenses/by/4.0/legalcode.en-
dc.rights.holderDi Tella, De Marco, Baglio, Silveri and Venneri-
Appears in Collections:Dept of Life Sciences Research Papers

Files in This Item:
File Description SizeFormat 
FullText.pdfCopyright © 2023 Di Tella, De Marco, Baglio, Silveri and Venneri. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.7.2 MBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons