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http://bura.brunel.ac.uk/handle/2438/27500Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Campanile, M | - |
| dc.contributor.author | Bettinelli, L | - |
| dc.contributor.author | Cerutti, C | - |
| dc.contributor.author | Spinetti, G | - |
| dc.date.accessioned | 2023-11-01T12:57:32Z | - |
| dc.date.available | 2023-10-17 | - |
| dc.date.available | 2023-11-01T12:57:32Z | - |
| dc.date.issued | 2023-10-17 | - |
| dc.identifier | ORCID i|D: Camilla Cerutti https://orcid.org/0000-0001-9426-686X | - |
| dc.identifier | 1261849 | - |
| dc.identifier.citation | Campanile, M. et al. (2023) 'Bone marrow vasculature advanced in vitro models for cancer and cardiovascular research', Frontiers in Cardiovascular Medicine, 10, 1261849, pp. 1 - 21. doi: 10.3389/fcvm.2023.1261849. | en_US |
| dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/27500 | - |
| dc.description.abstract | Copyright © 2023 Campanile, Bettinelli, Cerutti and Spinetti. Cardiometabolic diseases and cancer are among the most common diseases worldwide and are a serious concern to the healthcare system. These conditions, apparently distant, share common molecular and cellular determinants, that can represent targets for preventive and therapeutic approaches. The bone marrow plays an important role in this context as it is the main source of cells involved in cardiovascular regeneration, and one of the main sites of liquid and solid tumor metastasis, both characterized by the cellular trafficking across the bone marrow vasculature. The bone marrow vasculature has been widely studied in animal models, however, it is clear the need for human-specific in vitro models, that resemble the bone vasculature lined by endothelial cells to study the molecular mechanisms governing cell trafficking. In this review, we summarized the current knowledge on in vitro models of bone marrow vasculature developed for cardiovascular and cancer research. | en_US |
| dc.description.sponsorship | The author(s) declare financial support was received for the research, authorship, and/or publication of this article. MC and GS are supported by the Italian Ministry of Health (Ricerca Corrente and 5xmille to the IRCCS MultiMedica). CC is the recipient of the International Cancer Research Fellowship ICARE-2 funded from by the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 800924 (“Single-cell epigenetic and molecular signatures in human breast cancer metastasis formation). | en_US |
| dc.format.extent | 1 - 21 | - |
| dc.format.medium | Electronic | - |
| dc.language | English | - |
| dc.language.iso | en_US | en_US |
| dc.publisher | Frontiers Media | en_US |
| dc.rights | Copyright © 2023 Campanile, Bettinelli, Cerutti and Spinetti. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | - |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
| dc.subject | bone marrow vasculature | en_US |
| dc.subject | in vitro models | en_US |
| dc.subject | HSPC mobilization | en_US |
| dc.subject | cancer | en_US |
| dc.subject | diabetes | en_US |
| dc.title | Bone marrow vasculature advanced in vitro models for cancer and cardiovascular research | en_US |
| dc.type | Article | en_US |
| dc.identifier.doi | https://doi.org/10.3389/fcvm.2023.1261849 | - |
| dc.relation.isPartOf | Frontiers in Cardiovascular Medicine | - |
| pubs.publication-status | Published online | - |
| pubs.volume | 10 | - |
| dc.identifier.eissn | 2297-055X | - |
| dc.rights.holder | Campanile, Bettinelli, Cerutti and Spinetti | - |
| Appears in Collections: | Dept of Life Sciences Research Papers | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| FullText.pdf | Copyright © 2023 Campanile, Bettinelli, Cerutti and Spinetti. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | 12.17 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License
