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Please use this identifier to cite or link to this item: http://bura.brunel.ac.uk/handle/2438/27951
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dc.contributor.authorKanai, M-
dc.contributor.authorAndrews, SJ-
dc.contributor.authorCordioli, M-
dc.contributor.authorStevens, C-
dc.contributor.authorNeale, BM-
dc.contributor.authorDaly, M-
dc.contributor.authorGanna, A-
dc.contributor.authorPathak, GA-
dc.contributor.authorIwasaki, A-
dc.contributor.authorKarjalainen, J-
dc.contributor.authorMehtonen, J-
dc.contributor.authorPirinen, M-
dc.contributor.authorChwialkowska, K-
dc.contributor.authorTrankiem, A-
dc.contributor.authorBalaconis, MK-
dc.contributor.authorVeerapen, K-
dc.contributor.authorWolford, BN-
dc.contributor.authorAhmad, HF-
dc.contributor.authorAndrews, S-
dc.contributor.authorvon Hohenstaufen Puoti, KA-
dc.contributor.authorBoer, C-
dc.contributor.authorBoua, PR-
dc.contributor.authorButler-Laporte, G-
dc.contributor.authorCadilla, CL-
dc.contributor.authorColombo, F-
dc.contributor.authorDouillard, V-
dc.contributor.authorDueker, N-
dc.contributor.authorDutta, AK-
dc.contributor.authorEl-Sherbiny, YM-
dc.contributor.authorEltoukhy, MM-
dc.contributor.authorEsmaeeli, S-
dc.contributor.authorFaucon, A-
dc.contributor.authorFave, MJ-
dc.contributor.authorCadenas, IF-
dc.contributor.authorFrancescatto, M-
dc.contributor.authorFrancioli, L-
dc.contributor.authorFranke, L-
dc.contributor.authorFuentes, M-
dc.contributor.authorDurán, RG-
dc.contributor.authorCabrero, DG-
dc.contributor.authorHarry, EN-
dc.contributor.authorJansen, P-
dc.contributor.authorSzentpéteri, JL-
dc.contributor.authorKaja, E-
dc.contributor.authorKanai, M-
dc.contributor.authorKirk, C-
dc.contributor.authorKousathanas, A-
dc.contributor.authorKrieger, JE-
dc.contributor.authorPatel, SK-
dc.contributor.authorLemaçon, A-
dc.contributor.authorLimou, S-
dc.contributor.authorLió, P-
dc.contributor.authorMarouli, E-
dc.contributor.authorMarttila, MM-
dc.contributor.authorMedina-Gómez, C-
dc.contributor.authorMichaeli, Y-
dc.contributor.authorMigeotte, I-
dc.contributor.authorMondal, S-
dc.contributor.authorMoreno-Estrada, A-
dc.contributor.authorMoya, L-
dc.contributor.authorNakanishi, T-
dc.contributor.authorNasir, J-
dc.contributor.authorPasko, D-
dc.contributor.authorPearson, NM-
dc.contributor.authorPereira, AC-
dc.contributor.authorPriest, J-
dc.contributor.authorPrijatelj, V-
dc.contributor.authorProkic, I-
dc.contributor.authorTeumer, A-
dc.contributor.authorVárnai, R-
dc.contributor.authorRomero-Gómez, M-
dc.contributor.authorRoos, C-
dc.contributor.authorRosenfeld, J-
dc.contributor.authorRuolin, L-
dc.contributor.authorSchulte, EC-
dc.contributor.authorSchurmann, C-
dc.contributor.authorSedaghati-khayat, B-
dc.contributor.authorShaheen, D-
dc.contributor.authorShivanathan, I-
dc.contributor.authorSipeky, C-
dc.contributor.authorSirui, Z-
dc.contributor.authorStriano, P-
dc.contributor.authorTanigawa, Y-
dc.contributor.authorRemesal, AU-
dc.contributor.authorVadgama, N-
dc.contributor.authorVallerga, CL-
dc.contributor.authorvan der Laan, S-
dc.contributor.authorVerdugo, RA-
dc.contributor.authorWang, QS-
dc.contributor.authorWei, Z-
dc.contributor.authorZainulabid, UA-
dc.contributor.authorZárate, RN-
dc.contributor.authorAuton, A-
dc.contributor.authorShelton, JF-
dc.contributor.authorShastri, AJ-
dc.contributor.authorWeldon, CH-
dc.contributor.authorFilshtein-Sonmez, T-
dc.contributor.authorCoker, D-
dc.contributor.authorSymons, A-
dc.contributor.authorNolan, C-
dc.contributor.otherThe COVID-19 Host Genetics Initiative-
dc.date.accessioned2023-12-31T12:28:14Z-
dc.date.available2023-12-31T12:28:14Z-
dc.date.issued2023-09-06-
dc.identifierORCID iD: Claire Nolan https://orcid.org/0000-0001-9067-599X-
dc.identifier.citationKanai, M. et al. for the The COVID-19 Host Genetics Initiative (2023) 'A second update on mapping the human genetic architecture of COVID-19', Nature, 621 (7977), pp. E7 - E26. doi: 10.1038/s41586-023-06355-3.en_US
dc.identifier.issn0028-0836-
dc.identifier.urihttps://bura.brunel.ac.uk/handle/2438/27951-
dc.descriptionMatters Arising From: COVID-19 Host Genetics Initiative. Nature https://doi.org/10.1038/s41586-021-03767-x (2021)en_US
dc.descriptionData availability: Summary statistics generated by the COVID-19 HGI are available online, including per-ancestry summary statistics for African, admixed American, East Asian, European and South Asian ancestries (https://www.covid19hg.org/results/r7/). The analyses described here used the data release 7. If available, individual-level data can be requested directly from contributing studies, listed in Supplementary Table 1. We used publicly available data from GTEx (https://gtexportal.org/home/), the Neale laboratory (http://www.nealelab.is/uk-biobank/), the Finucane laboratory (https://www.finucanelab.org), the FinnGen Freeze 4 cohort (https://www.finngen.fi/en/access_results) and the eQTL catalogue release 3 (http://www.ebi.ac.uk/eqtl/).-
dc.descriptionCode availability: The code for summary statistics lift-over, the projection PCA pipeline including precomputed loadings and meta-analyses (https://github.com/covid19-hg/); for heritability estimation (https://github.com/AndrewsLabUCSF/COVID19_heritability); for Mendelian randomization and genetic correlation (https://github.com/marcoralab/MRcovid); and subtype analyses (https://github.com/mjpirinen/covid19-hgi_subtypes) are available at GitHub.-
dc.descriptionReporting summary: Further information on research design is available in the Nature Portfolio Reporting Summary linked to this article online at: https://www.nature.com/articles/s41586-023-06355-3#MOESM2 .-
dc.descriptionSupplementary information is available online at: https://www.nature.com/articles/s41586-023-06355-3#Sec4 .-
dc.description.abstractCopyright © The Author(s) 2023. Investigating the role of host genetic factors in COVID-19 severity and susceptibility can inform our understanding of the underlying biological mechanisms that influence adverse outcomes and drug development1,2. Here we present a second updated genome-wide association study (GWAS) on COVID-19 severity and infection susceptibility to SARS-CoV-2 from the COVID-19 Host Genetic Initiative (data release 7). We performed a meta-analysis of up to 219,692 cases and over 3 million controls, identifying 51 distinct genome-wide significant loci—adding 28 loci from the previous data release2. The increased number of candidate genes at the identified loci helped to map three major biological pathways that are involved in susceptibility and severity: viral entry, airway defence in mucus and type I interferon.en_US
dc.format.extentE7 - E26-
dc.format.mediumPrint-Electronic-
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.rightsCopyright © The Author(s) 2023. Rights and permissions: Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.-
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/-
dc.subjectgenetics-
dc.subjectgenome-wide association studies-
dc.subjectSARS-CoV-2-
dc.subjectviral infection-
dc.titleA second update on mapping the human genetic architecture of COVID-19en_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1038/s41586-023-06355-3-
dc.relation.isPartOfNature-
pubs.issue7977-
pubs.publication-statusPublished-
pubs.volume621-
dc.identifier.eissn1476-4687-
dc.rights.holderThe Author(s)-
Appears in Collections:Dept of Health Sciences Research Papers

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