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DC Field | Value | Language |
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dc.contributor.author | Mupunga, I | - |
dc.contributor.author | van Rensburg, IJ | - |
dc.contributor.author | Luthuli, N | - |
dc.contributor.author | Abafe, OA | - |
dc.contributor.author | Shai, LJ | - |
dc.contributor.author | Katerere, DR | - |
dc.date.accessioned | 2024-01-19T16:59:18Z | - |
dc.date.available | 2024-01-19T16:59:18Z | - |
dc.date.issued | 2021-08-16 | - |
dc.identifier | ORCID iD: Innocent Mupunga https://orcid.org/0000-0002-7616-9860 | - |
dc.identifier | ORCID iD: Ovokeroye A. Abafe https://orcid.org/0000-0002-5672-6463 | - |
dc.identifier | ORCID iD: Leshweni J. Shai https://orcid.org/0000-0003-4799-7437 | - |
dc.identifier | ORCID iD: David R. Katerere https://orcid.org/0000-0002-4606-294X | - |
dc.identifier | 570 | - |
dc.identifier.citation | Mupunga, I. et al. (2021) 'Analysis of aflatoxin biomarkers in the hair of experimental animals', Toxins, 13 (8), 570, pp. 1 - 11. doi: 10.3390/toxins13080570. | en_US |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/28056 | - |
dc.description | Data Availability Statement: Not applicable. | en_US |
dc.description.abstract | Copyright © 2021 by the authors. Analysis of body fluids and tissues of aflatoxin exposed individuals for the presence of aflatoxins and aflatoxin metabolites has emerged as a reliable indicator of exposure and metabolism of aflatoxins. However, current aflatoxin biomarkers are not appropriate for investigating the long-term effects of aflatoxin exposure. In this explorative study, we investigated the analysis of hair as a complementary or alternative matrix for the assessment of biomarkers of long-term aflatoxin exposure. Three groups of guinea pigs were orally dosed with 5 ugkg−1bw−1, 50 ugkg−1bw−1, and 100 ugkg−1bw−1 of AFB1. Urine and hair samples were collected on days 0, 1, 2, 3, 7, 30, 60, and 90 and analysed for AFB1 and AFM1 using UHPLC-MS/MS. AFB1 and AFM1 were detected in 75% and 13.6%, respectively, of the day 1 to day 7 urine samples. AFB1 was detected in hair samples collected from day 3 up to day 60. This is the first report to confirm the deposition of AFB1 in the hair of experimental animals. These findings indicate that hair analysis has the potential to provide an accurate long-term historical record of aflatoxin exposure with potentially important implications for the field of aflatoxin biomarkers. | en_US |
dc.description.sponsorship | This research received no external funding. | en_US |
dc.format.extent | 1 - 11 | - |
dc.format.medium | Electronic | - |
dc.language | English | - |
dc.language.iso | en_US | en_US |
dc.publisher | MDPI | en_US |
dc.rights | Copyright © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | aflatoxin | en_US |
dc.subject | biomarkers | en_US |
dc.subject | AFM1 | en_US |
dc.subject | AFB1 | en_US |
dc.subject | hair | en_US |
dc.subject | UHPLC-MS/MS | en_US |
dc.title | Analysis of aflatoxin biomarkers in the hair of experimental animals | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.3390/toxins13080570 | - |
dc.relation.isPartOf | Toxins | - |
pubs.issue | 8 | - |
pubs.publication-status | Published | - |
pubs.volume | 13 | - |
dc.identifier.eissn | 2072-6651 | - |
dc.rights.holder | The authors | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
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FullText.pdf | Copyright © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | 2.84 MB | Adobe PDF | View/Open |
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