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DC Field | Value | Language |
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dc.contributor.author | Migeri, S | - |
dc.contributor.author | Lawal, MA | - |
dc.contributor.author | Hughes, JC | - |
dc.contributor.author | Badza, T | - |
dc.contributor.author | Abafe, OA | - |
dc.contributor.author | Martincigh, BS | - |
dc.contributor.author | Odindo, AO | - |
dc.date.accessioned | 2024-02-03T09:13:38Z | - |
dc.date.available | 2024-02-03T09:13:38Z | - |
dc.date.issued | 2023-06-01 | - |
dc.identifier | ORCID iD: Ovokeroye A. Abafe https://orcid.org/0000-0002-5672-6463 | - |
dc.identifier | 164551 | - |
dc.identifier.citation | Migeri, S. et al. (2023) 'Uptake of selected antiretrovirals by pepper (Capsicum annum), radish (Raphanus sativus), and ryegrass (Lolium perenne) grown on two contrasting soils and fertilized with human urine-derived fertilizers', Science of the Total Environment, 892, 164551, pp. 1 - 9. doi: 10.1016/j.scitotenv.2023.164551. | en_US |
dc.identifier.issn | 0048-9697 | - |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/28184 | - |
dc.description | Data availability: Data will be made available on request. | en_US |
dc.description | Supplementary data are available online at: https://www.sciencedirect.com/science/article/pii/S0048969723031728?via%3Dihub#ac0005:~:text=Appendix%20A.-,Supplementary%20data,-Data%20availability . | - |
dc.description.abstract | Copyright © 2023 The Authors. The use of urine-derived fertilizers has several economic and environmental advantages. However, there is concern that pharmaceutical residues present in urine could enter the food chain after plant uptake and pose potential risks to human and animal health. A pot experiment was conducted to evaluate the uptake of nine target antiretroviral drugs (ARVDs) by pepper (Capsicum annum), ryegrass (Lolium perenne) and radish (Raphanus sativus) grown in two soils of contrasting texture and organic matter content and fertilized with stored urine, nitrified urine concentrate (NUC), and struvite. Nevirapine was the only ARVD detected in crops grown with NUC and struvite on both soils, but the concentrations were below the limit of quantification. Plants fertilized with stored urine absorbed lamivudine, ritonavir, stavudine, emtricitabine, nevirapine, and didanosine, while abacavir, efavirenz and zidovudine were not detected. The ARVDs detected in the soils after harvest were significantly higher in the soil with high organic matter and clay content. To assess direct human exposure the estimated daily dietary intake (DDI) of ARVDs by consumption of the pepper and radish fertilized with stored urine was compared with the Threshold of Toxicological Concern (TTC) values based on the Cramer classification tree. The calculated DDI values for all ARVDs were about 300–3000 times lower than the TTC values for class III compounds. Therefore, daily consumption of these crops fertilized with stored urine does not pose a health risk to the consumer. Future research is required to assess the impact of ARVD metabolites, which may be more harmful to human health than the parent compounds. | en_US |
dc.description.sponsorship | The authors thank the Water Research Commission of South Africa for financial support provided for this study (WRC K5/2777). | en_US |
dc.format.extent | 1 - 9 | - |
dc.format.medium | Print-Electronic | - |
dc.language | English | - |
dc.language.iso | en_US | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | Copyright © 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/). | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.subject | human urine fertilizers | en_US |
dc.subject | antiretroviral drugs | en_US |
dc.subject | plant uptake | en_US |
dc.subject | human health risk | en_US |
dc.title | Uptake of selected antiretrovirals by pepper (Capsicum annum), radish (Raphanus sativus), and ryegrass (Lolium perenne) grown on two contrasting soils and fertilized with human urine-derived fertilizers | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.1016/j.scitotenv.2023.164551 | - |
dc.relation.isPartOf | Science of the Total Environment | - |
pubs.publication-status | Published | - |
pubs.volume | 892 | - |
dc.identifier.eissn | 1879-1026 | - |
dc.rights.holder | The Authors | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
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