Please use this identifier to cite or link to this item: http://bura.brunel.ac.uk/handle/2438/28204
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dc.contributor.authorCreese, B-
dc.contributor.authorArathimos, R-
dc.contributor.authorAarsland, D-
dc.contributor.authorBallard, C-
dc.contributor.authorBrooker, H-
dc.contributor.authorHampshire, A-
dc.contributor.authorCorbett, A-
dc.contributor.authorIsmail, Z-
dc.date.accessioned2024-02-04T12:44:43Z-
dc.date.available2024-02-04T12:44:43Z-
dc.date.issued2023-04-30-
dc.identifierORCID iD: Byron Creese https://orcid.org/0000-0001-6490-6037-
dc.identifiere12386-
dc.identifier.citationCreese, B. et al. (2023) 'Late‐life onset psychotic symptoms and incident cognitive impairment in people without dementia: Modification by genetic risk for Alzheimer's disease', Alzheimer's & Dementia: Translational Research & Clinical Interventions, 9 (2), e12386, pp. 1 - 12. doi: 10.1002/trc2.12386.en_US
dc.identifier.urihttps://bura.brunel.ac.uk/handle/2438/28204-
dc.descriptionSupporting Information is available online at: https://doi.org/10.1002/trc2.12386 .en_US
dc.description.abstractIntroduction: Late-life onset psychosis is associated with faster progression to dementia in cognitively normal people, but little is known about its relationship with cognitive impairment in advance of dementia. Methods: Clinical and genetic data from 2750 people ≥50 years of age without dementia were analyzed. Incident cognitive impairment was operationalized using the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) and psychosis was rated using the Mild Behavioral Impairment Checklist (henceforth MBI-psychosis). The whole sample was analyzed before stratification on apolipoprotein E (APOE) ε4 status. Results: In Cox proportional hazards models, MBI-psychosis had a higher hazard for cognitive impairment relative to the No Psychosis group (hazard ratio [HR]: 3.6, 95% confidence interval [CI]: 2.2–6, p < 0.0001). The hazard for MBI-psychosis was higher in APOE ε4 carriers and there was an interaction between the two (HR for interaction: 3.4, 95% CI: 1.2–9.8, p = 0.02). Discussion: Psychosis assessment in the MBI framework is associated with incident cognitive impairment in advance of dementia. These symptoms may be particularly important in the context of APOE genotype.en_US
dc.format.extent1 - 12-
dc.format.mediumElectronic-
dc.languageEnglish-
dc.language.isoen_USen_US
dc.publisherWiley on behalf of Alzheimer's Associationen_US
dc.rightsCopyright © 2023 The Authors. Alzheimer's & Dementia: Translational Research & Clinical Interventions published by Wiley Periodicals LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.-
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/-
dc.subjectAPOEen_US
dc.subjectcognitionen_US
dc.subjectmild behavioral impairmenten_US
dc.subjectneuropsychiatric symptomsen_US
dc.subjectpsychosisen_US
dc.titleLate‐life onset psychotic symptoms and incident cognitive impairment in people without dementia: Modification by genetic risk for Alzheimer's diseaseen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1002/trc2.12386-
dc.relation.isPartOfAlzheimer's & Dementia: Translational Research & Clinical Interventions-
pubs.issue2-
pubs.publication-statusPublished-
pubs.volume9-
dc.identifier.eissn2352-8737-
dc.rights.holderThe Authors-
Appears in Collections:Dept of Life Sciences Research Papers

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