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Title: | Cross-adaptation from heat stress to hypoxia: A systematic review and exploratory meta-analysis |
Authors: | Willmott, AGB Diment, AG Chung, HC James, CA Maxwell, NS Roberts, JD Gibson, OR |
Issue Date: | 26-Jan-2024 |
Publisher: | Elsevier |
Citation: | Willmott, A.G.B. et al. (2024) 'Cross-adaptation from heat stress to hypoxia: A systematic review and exploratory meta-analysis', Journal of Thermal Biology 120, 103793 , pp. 1 - 14. doi: 10.1016/j.jtherbio.2024.103793. |
Abstract: | Cross-adaptation (CA) refers to the successful induction of physiological adaptation under one environmental stressor (e.g., heat), to enable subsequent benefit in another (e.g., hypoxia). This systematic review and exploratory meta-analysis investigated the effect of heat acclimation (HA) on physiological, perceptual and physical performance outcome measures during rest, and submaximal and maximal intensity exercise in hypoxia. Database searches in Scopus and MEDLINE were performed. Studies were included when they met the Population, Intervention, Comparison, and Outcome criteria, were of English-language, peer-reviewed, full-text original articles, using human participants. Risk of bias and study quality were assessed using the COnsensus based Standards for the selection of health status Measurement INstruments checklist. Nine studies were included, totalling 79 participants (100 % recreationally trained males). The most common method of HA included fixed-intensity exercise comprising 9 ± 3 sessions, 89 ± 24-min in duration and occurred within 39 ± 2 °C and 32 ± 13 % relative humidity. CA induced a moderate, beneficial effect on physiological measures at rest (oxygen saturation: g = 0.60) and during submaximal exercise (heart rate: g = −0.65, core temperature: g = −0.68 and skin temperature: g = −0.72). A small effect was found for ventilation (g = 0.24) and performance measures (peak power: g = 0.32 and time trial time: g = −0.43) during maximal intensity exercise. No effect was observed for perceptual outcome measures. CA may be appropriate for individuals, such as occupational or military workers, whose access to altitude exposure prior to undertaking submaximal activity in hypoxic conditions is restricted. Methodological variances exist within the current literature, and females and well-trained individuals have yet to be investigated. Future research should focus on these cohorts and explore the mechanistic underpinnings of CA. |
URI: | https://bura.brunel.ac.uk/handle/2438/28302 |
DOI: | https://doi.org/10.1016/j.jtherbio.2024.103793 |
ISSN: | 0306-4565 |
Other Identifiers: | ORCiD: Ashley G.B. Willmott https://orcid.org/0000-0001-7322-2569 ORCiD: Henry C. Chung https://orcid.org/0000-0003-3285-2892 ORCiD: Carl A. James https://orcid.org/0000-0003-2099-5343 ORCiD: Neil S. Maxwell https://orcid.org/0000-0002-0684-404X ORCiD: Justin D. Roberts https://orcid.org/0000-0002-3169-2041 ORCiD: Oliver R. Gibson https://orcid.org/0000-0001-6777-5562 103793 |
Appears in Collections: | Dept of Life Sciences Research Papers |
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FullText.pdf | Copyright © 2024 The Authors. Published by Elsevier Ltd..This is an open access article under a Creative Commons license (https://creativecommons.org/licenses/by/4.0/). | 3.45 MB | Adobe PDF | View/Open |
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