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DC Field | Value | Language |
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dc.contributor.author | Cresto, N | - |
dc.contributor.author | Forner-Piquer, I | - |
dc.contributor.author | Baig, A | - |
dc.contributor.author | Chatterjee, M | - |
dc.contributor.author | Perroy, J | - |
dc.contributor.author | Goracci, J | - |
dc.contributor.author | Marchi, N | - |
dc.date.accessioned | 2024-02-17T10:39:14Z | - |
dc.date.available | 2023-03-04 | - |
dc.date.available | 2024-02-17T10:39:14Z | - |
dc.date.issued | 2023-03-04 | - |
dc.identifier | ORCiD: Isabel Forner-Piquer https://orcid.org/0000-0002-5315-3858 | - |
dc.identifier | ORCiD: Asma Baig https://orcid.org/0000-0002-3764-1456 | - |
dc.identifier | ORCiD: Mousumi Chatterjee https://orcid.org/0000-0002-6561-3006 | - |
dc.identifier | 138251 | - |
dc.identifier.citation | Cresto, N. et al. (2023) 'Pesticides at brain borders: Impact on the blood-brain barrier, neuroinflammation, and neurological risk trajectories', Chemosphere, 324, 138251, pp. 1 - 17. doi: 10.1016/j.chemosphere.2023.138251. | en_US |
dc.identifier.issn | 0045-6535 | - |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/28330 | - |
dc.description | Data availability: No data was used for the research described in the article. | en_US |
dc.description.abstract | Pesticides are omnipresent, and they pose significant environmental and health risks. Translational studies indicate that acute exposure to high pesticide levels is detrimental, and prolonged contact with low concentrations of pesticides, as single and cocktail, could represent a risk factor for multi-organ pathophysiology, including the brain. Within this research template, we focus on pesticides' impact on the blood-brain barrier (BBB) and neuroinflammation, physical and immunological borders for the homeostatic control of the central nervous system (CNS) neuronal networks. We examine the evidence supporting a link between pre- and postnatal pesticide exposure, neuroinflammatory responses, and time-depend vulnerability footprints in the brain. Because of the pathological influence of BBB damage and inflammation on neuronal transmission from early development, varying exposures to pesticides could represent a danger, perhaps accelerating adverse neurological trajectories during aging. Refining our understanding of how pesticides influence brain barriers and borders could enable the implementation of pesticide-specific regulatory measures directly relevant to environmental neuroethics, the exposome, and one-health frameworks. | en_US |
dc.description.sponsorship | This work was supported by ANR-Hepatobrain, Anses-Epidimicmac, iMUSE Pestifish to NM, and iMUSE Envirodisorders to NM and JP; partially supported by Anses-OptoFish, ANR-EpiNeurAge, ANR/Era-Net Neu-Vasc to NM. MC is thankful to Daphne Jackson Trust (UK) for her fellowship. JG is grateful to the EU project Agromix. | en_US |
dc.format.extent | 1 - 17 | - |
dc.format.medium | Print-Electronic | - |
dc.language | English | - |
dc.language.iso | en_US | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | Copyright © Elsevier. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ (see: https://www.elsevier.com/about/policies/sharing). | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.subject | pesticides | en_US |
dc.subject | neuro-glio-vascular unit | en_US |
dc.subject | neuroinflammation | en_US |
dc.subject | neurological disorders | en_US |
dc.subject | astrocytes | en_US |
dc.subject | microglia | en_US |
dc.subject | zebrafish | en_US |
dc.subject | rodent models | en_US |
dc.subject | humans | en_US |
dc.title | Pesticides at brain borders: Impact on the blood-brain barrier, neuroinflammation, and neurological risk trajectories | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.1016/j.chemosphere.2023.138251 | - |
dc.relation.isPartOf | Chemosphere | - |
pubs.publication-status | Published | - |
pubs.volume | 324 | - |
dc.identifier.eissn | 1879-1298 | - |
dc.rights.holder | Elsevier | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
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FullText.pdf | Copyright © Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ (see: https://www.elsevier.com/about/policies/sharing). | 1.39 MB | Adobe PDF | View/Open |
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