Please use this identifier to cite or link to this item:
http://bura.brunel.ac.uk/handle/2438/28825
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Maslova, E | - |
dc.contributor.author | EisaianKhongi, L | - |
dc.contributor.author | Rigole, P | - |
dc.contributor.author | Coenye, T | - |
dc.contributor.author | McCarthy, RR | - |
dc.date.accessioned | 2024-04-20T14:02:07Z | - |
dc.date.available | 2024-04-20T14:02:07Z | - |
dc.date.issued | 2024-06-25 | - |
dc.identifier | ORCiD: Tom Coenye http://orcid.org/0000-0002-6407-0601 | - |
dc.identifier | ORCiD: Ronan R McCarthy https://orcid.org/0000-0002-7480-6352 | - |
dc.identifier | 52 | - |
dc.identifier.citation | Maslova, E. et al. (2024) 'Carbon source competition within the wound microenvironment can significantly influence infection progression.', npj Biofilms and Microbiomes, 10, 52, pp. 1 - 10. doi: 10.1038/s41522-024-00518-4. | en_US |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/28825 | - |
dc.description | Data availability: The RNA-seq datasets produced in this study are available at the National Center for Biotechnology Information Gene Expression Omnibus public database under accession number GSE236405. | en_US |
dc.description.abstract | It is becoming increasingly apparent that commensal skin bacteria have an important role in wound healing and infection progression. However, the precise mechanisms underpinning many of these probiotic interactions remain to be fully uncovered. In this work, we demonstrate that the common skin commensal Cutibacterium acnes can limit the pathogenicity of the prevalent wound pathogen Pseudomonas aeruginosa in vivo. We show that this impact on pathogenicity is independent of any effect on growth, but occurs through a significant downregulation of the Type Three Secretion System (T3SS), the primary toxin secretion system utilised by P. aeruginosa in eukaryotic infection. We also show a downregulation in glucose acquisition systems, a known regulator of the T3SS, suggesting that glucose availability in a wound can influence infection progression. C. acnes is well known as a glucose fermenting organism, and we demonstrate that topically supplementing a wound with glucose reverses the probiotic effects of C. acnes. This suggests that introducing carbon source competition within the wound microenvironment may be an effective way to prevent or limit wound infection. | en_US |
dc.description.sponsorship | R.R.M.C. is supported by the British Society for Antimicrobial Chemotherapy BSAC-2018-0095. R.R.M.C. and E.M. are supported by the NC3Rs PhD Studentship NC/V001582/1. R.R.M.C. is supported by a Biotechnology and Biological Sciences Research Council New Investigator Award BB/V007823/1 and Medical Research Council Grant MR/Y001354/1. R.R.M.C. is also supported by the Academy of Medical Sciences/the Wellcome Trust/the Government Department of Business, Energy and Industrial Strategy/the British Heart Foundation/Diabetes UK Springboard Award [SBF006\1040]. | en_US |
dc.format.extent | 1 - 10 | - |
dc.format.medium | Electronic | - |
dc.language.iso | en_US | en_US |
dc.publisher | Nature Research (part of Springer Nature) | en_US |
dc.rights | Copyright © The Author(s) 2024. Rights and permissions: Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/. | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | wound | en_US |
dc.subject | infection | en_US |
dc.subject | interspecies competition | en_US |
dc.subject | burn | en_US |
dc.subject | biofilm | en_US |
dc.subject | Pseudomonas aeruginosa | en_US |
dc.subject | Cutibacterium acnes | en_US |
dc.title | Carbon source competition within the wound microenvironment can significantly influence infection progression. | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.1038/s41522-024-00518-4 | - |
dc.relation.isPartOf | npj Biofilms and Microbiomes | - |
pubs.publication-status | Published online | - |
pubs.volume | 10 | - |
dc.rights.license | https://creativecommons.org/licenses/by/4.0/legalcode.en | - |
dc.rights.holder | The Author(s) | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
FullText.pdf | Copyright © The Author(s) 2024. Rights and permissions: Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/. | 1.44 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License