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DC Field | Value | Language |
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dc.contributor.author | Arduino, I | - |
dc.contributor.author | Santoro, A | - |
dc.contributor.author | De Santis, S | - |
dc.contributor.author | Iacobazzi, RM | - |
dc.contributor.author | Lopedota, AA | - |
dc.contributor.author | Paradies, E | - |
dc.contributor.author | Merla, G | - |
dc.contributor.author | Anjomani Virmouni, S | - |
dc.contributor.author | Palmieri, L | - |
dc.contributor.author | Thomas Marobbio, CM | - |
dc.contributor.author | Denora, N | - |
dc.date.accessioned | 2024-06-06T14:40:58Z | - |
dc.date.available | 2024-06-06T14:40:58Z | - |
dc.date.issued | 2024-06-03 | - |
dc.identifier | ORCiD: Antonella Santoro https://orcid.org/0000-0002-6193-2050 | - |
dc.identifier | ORCiD: Eleonora Paradies https://orcid.org/0000-0002-1668-7148 | - |
dc.identifier | ORCiD: Sara Anjomani Virmouni https://orcid.org/0000-0001-5831-780X | - |
dc.identifier | ORCiD: Nunzio Denora https://orcid.org/0000-0002-7756-7828 | - |
dc.identifier | 105837 | - |
dc.identifier.citation | Arduino, I. et al. (2024) 'Microfluidic formulation of diazoxide-loaded solid lipid nanoparticles as a Novel approach for Friedreich's ataxia treatment', Journal of Drug Delivery Science and Technology, 97, 105837, pp. 1 - 9. doi: 10.1016/j.jddst.2024.105837. | en_US |
dc.identifier.issn | 1773-2247 | - |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/29135 | - |
dc.description | Data availability: Data will be made available on request. | en_US |
dc.description.abstract | Friedreich ataxia (FRDA) is a hereditary autosomal recessive disorder characterized by frataxin deficiency, impacting mitochondrial function and causing oxidative damage. Diazoxide (DZX), a vasodilating drug used in the management of systemic hypertension, has shown promise in preclinical models but faces challenges in crossing the blood-brain barrier and potential toxicity at higher doses. This study aimed to create solid lipid nanoparticles (SLNs) loaded with DZX by microfluidic technique to improve blood-brain barrier (BBB) penetration and reduce side effects. Employing an in vitro BBB model, SLN-DZX demonstrated enhanced permeability compared to plain DZX. Cell viability assays carried out on FRDA fibroblast cells indicated enhanced viability with 1 μM SLN-DZX. Cellular uptake studies confirmed SLN internalization in FRDA fibroblasts, and subsequent treatment with SLN-DZX significantly reduced both total and mitochondrial ROS levels compared to control and empty SLN-treated cells. These findings suggest SLN-DZX as a potential therapeutic approach for FRDA, mitigating oxidative stress with improved BBB penetration and reduced toxicity. | en_US |
dc.description.sponsorship | M.I.U.R.—Programma Operativo Nazionale (PON) “Ricerca e Innovazione” 2014–2020 Tematica IV.4 “Dottorati e Contratti di ricerca su tematiche dell’innovazione”. | en_US |
dc.format.extent | 1 - 9 | - |
dc.format.medium | Print-Electronic | - |
dc.language | English | - |
dc.language.iso | en_US | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | Copyright © 2024 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (https://creativecommons.org/licenses/by/4.0/). | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | solid lipid nanoparticles | en_US |
dc.subject | microfluidics | en_US |
dc.subject | Friedreich ataxia | en_US |
dc.subject | blood-brain barrier delivery | en_US |
dc.title | Microfluidic formulation of diazoxide-loaded solid lipid nanoparticles as a Novel approach for Friedreich's ataxia treatment | en_US |
dc.type | Article | en_US |
dc.date.dateAccepted | 2024-06-01 | - |
dc.identifier.doi | https://doi.org/10.1016/j.jddst.2024.105837 | - |
dc.relation.isPartOf | Journal of Drug Delivery Science and Technology | - |
pubs.issue | in press, pre-proof | - |
pubs.publication-status | Published | - |
pubs.volume | 97 | - |
dc.identifier.eissn | 2588-8943 | - |
dc.rights.license | https://creativecommons.org/licenses/by/4.0/legalcode.en | - |
dc.rights.holder | The Authors | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
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FullText.pdf | Copyright © 2024 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (https://creativecommons.org/licenses/by/4.0/). | 3.01 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License