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Title: | The “Road” to Malignant Transformation from Endometriosis to Endometriosis-Associated Ovarian Cancers (EAOCs): An mTOR-Centred Review |
Authors: | Hablase, R Kyrou, I Randeva, H Karteris, E Chatterjee, J |
Keywords: | ovarian cancer;mTOR;endometriosis;endometrioid ovarian carcinoma;clear-cell carcinoma;mTOR inhibitors |
Issue Date: | 6-Jun-2024 |
Publisher: | MDPI |
Citation: | Hablase, R. et al. (2024) 'The “Road” to Malignant Transformation from Endometriosis to Endometriosis-Associated Ovarian Cancers (EAOCs): An mTOR-Centred Review', Cancers, 16 (11), 2160, pp. 1 - 28. doi: 10.3390/cancers16112160. |
Abstract: | Ovarian cancer is an umbrella term covering a number of distinct subtypes. Endometrioid and clear-cell ovarian carcinoma are endometriosis-associated ovarian cancers (EAOCs) frequently arising from ectopic endometrium in the ovary. The mechanistic target of rapamycin (mTOR) is a crucial regulator of cellular homeostasis and is dysregulated in both endometriosis and endometriosis-associated ovarian cancer, potentially favouring carcinogenesis across a spectrum from benign disease with cancer-like characteristics, through an atypical phase, to frank malignancy. In this review, we focus on mTOR dysregulation in endometriosis and EAOCs, investigating cancer driver gene mutations and their potential interaction with the mTOR pathway. Additionally, we explore the complex pathogenesis of transformation, considering environmental, hormonal, and epigenetic factors. We then discuss postmenopausal endometriosis pathogenesis and propensity for malignant transformation. Finally, we summarize the current advancements in mTOR-targeted therapeutics for endometriosis and EAOCs. |
Description: | Data Availability Statement: No extra data is generated in this review article. |
URI: | https://bura.brunel.ac.uk/handle/2438/29361 |
DOI: | https://doi.org/10.3390/cancers16112160 |
Other Identifiers: | ORCiD: Ioannis Kyrou https://orcid.org/0000-0002-6997-3439 ORCiD: https://orcid.org/0000-0003-3231-7267 ORCiD: Jayanta Chatterjee https://orcid.org/0000-0002-1770-4835 2160 |
Appears in Collections: | Dept of Life Sciences Research Papers |
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