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DC Field | Value | Language |
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dc.contributor.author | Uhl, LFK | - |
dc.contributor.author | Cai, H | - |
dc.contributor.author | Oram, SL | - |
dc.contributor.author | Mahale, JN | - |
dc.contributor.author | MacLean, AJ | - |
dc.contributor.author | Mazet, JM | - |
dc.contributor.author | Piccirilli, T | - |
dc.contributor.author | He, AJ | - |
dc.contributor.author | Lau, D | - |
dc.contributor.author | Elliott, T | - |
dc.contributor.author | Gerard, A | - |
dc.date.accessioned | 2024-07-24T11:55:13Z | - |
dc.date.available | 2024-07-24T11:55:13Z | - |
dc.date.issued | 2023-10-23 | - |
dc.identifier | ORCiD: Lion F. K. Uhl https://orcid.org/0000-0003-1729-9857 | - |
dc.identifier | ORCiD: Doreen Lau https://orcid.org/0000-0002-7623-2401 | - |
dc.identifier | ORCiD: Tim Elliott https://orcid.org/0000-0003-1097-0222 | - |
dc.identifier | ORCiD: Audrey Gerard https://orcid.org/0000-0003-3059-3065 | - |
dc.identifier | 6727 | - |
dc.identifier.citation | Uhl, L.F.K. et al. (2023) 'Interferon-γ couples CD8<sup>+</sup> T cell avidity and differentiation during infection', Nature Communications, 14 (1), 6727, pp. 1 - 17. doi: 10.1038/s41467-023-42455-4. | en_US |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/29404 | - |
dc.description | Data availability: The mouse scRNAseq and scTCRseq data generated in this study have been deposited in the GEO database under accession code GSE244203 (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE244203). Datasets reused in this study: EGAS00001005493 [44] (https://ega-archive.org/studies/EGAS00001005493). All data are included in the Supplementary Information or available from the authors upon reasonable requests, as are unique reagents used in this Article. The raw numbers for charts and graphs are available in the Source Data file whenever possible. Source data (https://www.nature.com/articles/s41467-023-42455-4#Sec26) are provided with this paper. | en_US |
dc.description | Supplementary information is available online at: https://www.nature.com/articles/s41467-023-42455-4#Sec25 . | - |
dc.description.abstract | Effective responses to intracellular pathogens are characterized by T cell clones with a broad affinity range for their cognate peptide and diverse functional phenotypes. How T cell clones are selected throughout the response to retain a breadth of avidities remains unclear. Here, we demonstrate that direct sensing of the cytokine IFN-γ by CD8+ T cells coordinates avidity and differentiation during infection. IFN-γ promotes the expansion of low-avidity T cells, allowing them to overcome the selective advantage of high-avidity T cells, whilst reinforcing high-avidity T cell entry into the memory pool, thus reducing the average avidity of the primary response and increasing that of the memory response. IFN-γ in this context is mainly provided by virtual memory T cells, an antigen-inexperienced subset with memory features. Overall, we propose that IFN-γ and virtual memory T cells fulfil a critical immunoregulatory role by enabling the coordination of T cell avidity and fate. | en_US |
dc.description.sponsorship | This research was funded in whole, or in part, by the UKRI (BBSRC BB/R015651/1 to A.G.), Cancer Research UK (CR-UK) (C5255/A18085 through the Cancer Research UK Oxford Centre and 29549 to A.G); the Kennedy Trust for Rheumatology Research (KENN151607 and KENN202112 to A.G), John Fell Funds (0006162 to A.G), MLSTF funds (to A.G) and Kennedy Studentship (to L.F.K.U). | en_US |
dc.format.extent | 1 - 17 | - |
dc.format.medium | Electronic | - |
dc.language | English | - |
dc.language.iso | en_US | en_US |
dc.publisher | Nature Research (part of Springer Nature) | en_US |
dc.rights | Copyright © The Author(s) 2023. Rights and permissions: Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | cytokines | en_US |
dc.subject | lymphocyte differentiation | en_US |
dc.title | Interferon-γ couples CD8<sup>+</sup> T cell avidity and differentiation during infection | en_US |
dc.title.alternative | Interferon-γ couples CD8+ T cell avidity and differentiation during infection | en_US |
dc.type | Article | en_US |
dc.date.dateAccepted | 2023-10-11 | - |
dc.identifier.doi | https://doi.org/10.1038/s41467-023-42455-4 | - |
dc.relation.isPartOf | Nature Communications | - |
pubs.issue | 1 | - |
pubs.publication-status | Published | - |
pubs.volume | 14 | - |
dc.identifier.eissn | 2041-1723 | - |
dc.rights.license | https://creativecommons.org/licenses/by/4.0/legalcode.en | - |
dc.rights.holder | The Author(s) | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
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